DOSE SETTING MECHANISM FOR PRIMING A DRUG DELIVERY DEVICE

• US 20100324528A1
• Filed: 05/27/2010
• Published: 12/23/2010
• Est. Priority Date: 06/01/2009
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: JONES, Christopher John, PLUMPTRE, David Aubrey, VEASEY, Robert Frederick
• Granted Patent: US 8,585,656 B2
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/2492 via snap connection
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31536 Blocking means to immobilize a selected dose, e.g. to administer equal doses
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/347 rotatable, e.g. bayonet or screw A61M5/344 takes precedence
• CPC Class Codes: A61M 5/348 snap lock, i.e. upon axial displacement of needle assembly A61M5/344 takes precedence

Abstract

A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Claims

1. A dose setting mechanism for a drug delivery device comprising:

a dial sleeve; and

an internal housing portion,

wherein the dial sleeve is coupled to the internal housing portion,

wherein the dial sleeve rotates along a substantially rotational path during priming of the drug delivery device, and

wherein the dial sleeve translates along a helical path during dose setting of the drug delivery device.

2. The invention of claim 1, wherein the internal housing comprises a threaded portion, and wherein the threaded portion comprises a rotational threaded portion and a helical threaded portion.

3. The invention of claim 2, wherein the dial sleeve rotates on the rotational threaded portion during priming of the drug delivery device, and wherein the dial sleeve translates along the helical threaded portion during dose setting of the drug delivery device.

4. The invention of claim 1, wherein the dial sleeve is prevented from rotating on the helical path prior to the priming of the drug delivery device.

5. The invention of claim 1, further comprising at least one non-return element disposed on the dial sleeve.

6. The invention of claim 5, further comprising at least one complimentary non-return element disposed on the internal housing portion that is complimentary to the at least one non-return element disposed on the dial sleeve.

7. The invention of claim 6, wherein the substantially rotational path comprises an end of the rotational path, wherein, when the dial sleeve substantially reaches the end of the rotational path, the at least one non-return element and the at least one complimentary non-return element interact to prevent substantial movement of the dial sleeve back along the rotational path.

8. The invention of claim 6, wherein the non-return element is a protrusion from the dial sleeve, and wherein the complimentary non-return element is a protrusion from the internal housing.

9. The invention of claim 8, wherein the non return element is connected to a flexible element portion of the dial sleeve, wherein the flexible element allows for the non-return element to pass over the complimentary non-return element during the rotational movement, and wherein, at the end of the substantially rotational path, the flexible element operates to prevent the non-return element to pass back over the complimentary non-return element.

10. The invention of claim 1, wherein the dose setting mechanism is coupled to a cartridge housing.

11. The invention of claim 10, wherein the dose setting mechanism and cartridge housing are coupled via a non-reversible coupling.

12. The invention of claim 1, wherein the dial sleeve comprises a graphic that is displayed prior to the priming, wherein the graphic indicates that the drug delivery device has not been primed.

13. The invention of claim 1, wherein the dose setting mechanism further comprises:

a driver; and

a spindle, wherein the dial sleeve is operatively coupled to the driver,

such that rotation of the dial sleeve causes the driver to rotate and the spindle to translate in a distal direction, this translation priming the drug delivery device.

14. The invention of claim 1, wherein the drug delivery device is non-reusable.

15. The invention of claim 1, wherein the drug delivery device is reusable.

16. The invention of claim 15, further comprising:

at least one non-return element disposed on the dose dial sleeve;

at least one complimentary non-return element disposed on the internal housing portion that is complimentary to the at least one non-return element disposed on the dose dial sleeve,

wherein, when a user is setting a dose, the non-return element and complimentary non-return element prevent substantial rotational movement along the substantially circumferential rotational path, and

wherein, when the user is not setting a dose, the non-return element and complimentary non-return element are capable of being overcome by a user of the device.

17. A method of priming a drug delivery device, the method comprising:

providing a dose dial sleeve engaged with an inner housing of a drug delivery device;

rotating the dose dial sleeve on a substantially circumferential rotational path around the inner housing, wherein rotating the dose dial sleeve primes the drug delivery device.

18. The invention of claim 17, further comprising:

responsive to the priming of the drug delivery device, preventing the dose dial sleeve from rotating circumferentially.

19. The invention of claim 18, wherein preventing the dose dial sleeve from rotating circumferentially comprises providing non-return features on the dose dial sleeve that interact with corresponding non-return features on the inner housing.

20. The invention of claim 19, further comprising:

providing a substantially circumferential rotational thread on the inner housing, wherein rotating the dose dial sleeve on a substantially circumferential rotational path around the inner housing comprises rotating the dose dial sleeve along the substantially circumferential rotational thread.