ORAL CARE PRODUCT AND METHODS OF USE AND MANUFACTURE THEREOF

• US 20100330003A1
• Filed: 02/06/2009
• Published: 12/30/2010
• Est. Priority Date: 02/08/2008
• Status: Active Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Ellwood, Roger, Sullivan, Richard J., Robinson, Richard Scott, Cummins, Diane
• Application Number:
  US12/866,786
• Publication Number:
  US 20100330003A1
• Time in Patent Office: Days
• US Class Current: 424/52
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 33/16 Fluorine compounds
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to methods of treating early enamel lesions comprising applying an effective amount of a basic amino acid in free or salt form, together with fluoride to a patient in need thereof.

Claims

1. A method of treating early enamel caries comprising:

applying an effective amount of a dentifrice composition to the oral cavity, the dentifrice composition having a base formulation comprising calcium carbonate, the dentifrice composition further comprising

arginine, in free or salt form, and

an effective amount of a fluoride ion source, wherein the arginine is provided in the amount of from 2 to 10 wt % based on the total weight of the dentifrice composition.

3. The method of claim 1 wherein the early enamel caries are detected by quantitative light-induced fluorescence (QLF) or electrical caries monitoring (ECM).

11. The method of claim 1 which is additionally effective to

a. inhibit formation of dental caries,

b. reduce or inhibit demineralization and promote remineralization of the teeth,

c. reduce hypersensitivity of the teeth,

d. reduce or inhibit gingivitis,

e. promote healing of sores or cuts in the mouth,

f. reduce levels of acid producing bacteria,

g. increase relative levels of arginolytic bacteria,

h. inhibit microbial biofilm formation in the oral cavi

i. raise and/or maintain plaque pH at levels of at least about pH 5.5 following sugar challenge,

j. reduce plaque accumulation,

k. treat, relieve or reduce dry mouth,

l. whiten teeth,

m. promote systemic health, including cardiovascular health,

n. reduce erosion of the teeth,

o. immunize or protect the teeth against cariogenic bacteria,

p. protect against cavities, and/or

q. clean the teeth and oral cavity.

19. The method of claim 1, wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.

20. The method of claim 1, wherein the dentifrice composition further comprises a potassium ion source.

21. The method of claim 20, wherein said potassium ion source is selected from potassium nitrate and potassium chloride.

2. (canceled)

4. A method to improve the quantitative light-induced fluorescence (QLF) or electrical caries monitoring (ECM) value, correlating to early enamel lesions, comprising:

applying an effective amount of a dentifrice composition to the oral cavity, the dentifrice composition having a base formulation comprising calcium carbonate, the dentifrice composition further comprising

arginine, in free or salt form, and

an effective amount of a fluoride ion source, wherein the arginine is provided in the amount of from 2 to 10 wt % based on the total weight of the dentifrice composition.

22. The method of claim 4, wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.

23. The method of claim 22, wherein the dentifrice composition further comprises a potassium ion source.

24. The method of claim 23, wherein said potassium ion source is selected from potassium nitrate and potassium chloride.

5-6. -6. (canceled)

7. A method to reduce the size of existing early enamel lesions, comprising:

applying an effective amount of a dentifrice composition to the oral cavity, the dentifrice composition having a base formulation comprising calcium carbonate, the dentifrice composition further comprising

arginine, in free or salt form, and

an effective amount of a fluoride ion source, wherein the arginine is provided in an amount of from 2 to 10 wt % based on the total weight of the dentifrice composition.

25. The method of claim 7, wherein the fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.

26. The method of claim 25, wherein the dentifrice composition further comprises a potassium ion source.

27. The method of claim 26, wherein said potassium ion source is selected from potassium nitrate and potassium chloride.

8-10. -10. (canceled)

12-18. -18. (canceled)