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IMMUNOGLOBULIN FC POLYPEPTIDES

  • US 20100330076A1
  • Filed: 06/30/2010
  • Published: 12/30/2010
  • Est. Priority Date: 06/30/2009
  • Status: Active Grant
First Claim
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1. A polypeptide comprising an aglycosylated antibody Fc domain capable of binding a human FcR polypeptide, wherein the Fc domain comprises an amino acid substitution at amino acids 382 and 428 and at least one additional substitution of any of the following amino acids:

  • 224, 241, 251, 266, 269, 276, 279, 286, 295, 297, 300, 315, 325, 328, 330, 331, 332, 338, 340, 341, 348, 369, 378, 382, 392, 424, 426, 428 and/or 434.

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