INJECTION VEHICLE FOR POLYMER-BASED FORMULATIONS
First Claim
1. An injection vehicle comprising hyaluronic acid or a derivative thereof at a concentration of about 0.01 to about 0.8 percent by volume.
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Accused Products
Abstract
The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of manufacture, and kits. Other aspects of the invention included methods for producing and administering pharmaceutical formulations. The injection vehicles of the invention are superior to conventional injection vehicles in that they include a pseudoplastic composition that improves injectability, which facilitates delivery of the desired dose. The injection vehicles of the invention also allow the use of smaller-bore needles than are usually necessary to inject polymer-based formulations, reducing the pain associated with injection of such formulations.
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Citations
20 Claims
- 1. An injection vehicle comprising hyaluronic acid or a derivative thereof at a concentration of about 0.01 to about 0.8 percent by volume.
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4. A pharmaceutical formulation comprising:
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(a) an effective amount of a biologically active agent in particulate form or coated on, dispersed within, or accompanied by particles; and (b) an injection vehicle comprising hyaluronic acid or a derivative thereof. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A pharmaceutical formulation comprising:
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(a) particles comprising a biocompatible polymeric matrix comprising a poly(lactide-co-glycolide) polymer; (b) an effective amount of a biologically active polypeptide dispersed within the polymeric matrix; and (c) an injection vehicle comprising hyaluronic acid or a derivative thereof. - View Dependent Claims (20)
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18. A method for producing a pharmaceutical formulation comprising:
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adding an effective amount of a biologically active agent in particulate form or coated on, dispersed within, or accompanied by particles to an injection vehicle comprising hyaluronic acid or a derivative thereof. - View Dependent Claims (19)
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Specification