METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR PROVIDING BOTH AN ESTIMATED TRUE MEAN BLOOD GLUCOSE VALUE AND ESTIMATED GLYCATED HEMOGLOBIN (HbA1C) VALUE FROM STRUCTURED SPOT MEASUREMENTS OF BLOOD GLUCOSE

• US 20100330598A1
• Filed: 06/26/2009
• Published: 12/30/2010
• Est. Priority Date: 06/26/2009
• Status: Abandoned Application

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Pan, Zhengzheng, Weinert, Stefan, Thukral, Ajay
• Application Number:
  US12/492,667
• Publication Number:
  US 20100330598A1
• Time in Patent Office: Days
• US Class Current: 435/14
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets

Abstract

A method and system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements are disclosed. The bG measurements and associated context of the bG measurement are collected at daily times specified by a structured sampling schema, and the collected bG measurements are weighted based on the associated context. The estimated true mean bG value and the estimate HbA1C value are then determined from the weighted measurements of the collected bG measurements. A computer program for implementing the method for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements is also disclosed.

Claims

1. A method for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements of a patient comprising:

collecting both bG measurements and associated context of the bG measurement at daily times and events specified by a structured sampling schema;

weighting each of the collected bG measurements based on the associated context;

determining the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements; and

providing the estimated true mean bG and the estimate HbA1C values.

2. The method according to claim 1 wherein the daily times specified by the structured sampling schema are post-prandial times.

3. The method according to claim 1 wherein the daily times specified by the structured sampling schema are three post-prandial times and another time.

4. The method according to claim 1 wherein one of the events specified by the structured sampling schema is a specific time with respect to start of a meal.

5. The method according to claim 1 wherein one of the events specified by the structured sampling schema is an aspect of glucose behavior related to the estimated true mean bG value.

6. The method according to claim 5 wherein the aspect is a bG mean to peak value.

7. The method according to claim 1 wherein the daily times specified by the structured sampling schema are at about 140 to about 240 minutes after a meal time.

8. The method according to claim 1 wherein the daily times and the events specified by a structured sampling schema are tailored to a daily lifestyle pattern of the patient.

9. The method according to claim 8 wherein the daily times specified by the structured sampling schema range from about 140 to about 240 minutes after a meal time in accordance with the daily lifestyle pattern of the patient.

10. The method according to claim 1 wherein the structured sampling schema requires collection of the bG measurement within a time interval from the daily times specified by the structured sampling schema in order for a bG measurement to be weighted.

11. The method according to claim 10 wherein the time interval is at most ±

50 minutes.

12. The method according to claim 1 wherein the structured sampling schema requires collection of a predetermined amount of the bG measurements per each of the daily times and the events before the method can provide the estimated true mean bG and the estimate HbA1C values.

13. The method according to claim 1 wherein the structured sampling schema requires collection of the bG measurements within a predetermined period before the method can provide the estimated true mean bG and the estimate HbA1C values.

14. The method according to claim 1 wherein the structured sampling schema requires collection of at least a predetermined amount of the bG measurements per each of the daily times and the events within a predetermined period before the method can provide the estimated true mean bG and the estimate HbA1C values.

15. The method according to claim 1 wherein the weighting is based on both duration between meals and age of bG measurements.

16. The method according to claim 1 wherein the weighting is based on harmonic temporal weighting.

17. The method according to claim 1 wherein the collected bG measurements older than 120 days have a weight of zero.

18. The method according to claim 1 wherein the estimated true mean bG value ( bG) is determined by averaging mean bG values for the daily times, each being defined as:

19. The method according to claim 1 wherein the estimate HbA1C value is determined by solving the equation:

0.033 bG+0.5702, where bG is the estimated true mean bG value.

20. The method according to claim 19 wherein the estimate HbA1C value is determined by solving the equation:

0.033 bG+0.5702, where bG is the estimated true mean bG value.

45. A computer program comprising code that when executed by a processor based system performs the steps of method claim 1.

21. A system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements comprising:

a display;

memory; and

a processor programmed;

to collect both bG measurements and associated context of the bG measurement at daily times and events specified by a structured sampling schema provided in memory;

to weight each of the collected bG measurements based on the associated context;

to determine the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements; and

to provide the estimated true mean bG and the estimate HbA1C values to the display.

22. The system according to claim 21 wherein the daily times specified by the structured sampling schema are post-prandial times.

23. The system according to claim 21 wherein the daily times specified by the structured sampling schema are three post-prandial times and another time.

24. The system according to claim 21 wherein one of the events specified by the structured sampling schema is a specific time with respect to start of a meal.

25. The system according to claim 21 wherein one of the events specified by the structured sampling schema is an aspect of glucose behavior related to the estimated true mean bG value.

26. The system according to claim 25 wherein the aspect is a bG mean to peak value.

27. The system according to claim 21 wherein the daily times specified by the structured sampling schema are at about 140 to about 240 minutes after a meal time.

28. The system according to claim 21 wherein the daily times and the events specified by a structured sampling schema are tailored to a daily lifestyle pattern of the patient.

29. The system according to claim 28 wherein the daily times specified by the structured sampling schema range from about 140 to about 240 minutes after a meal time in accordance with the daily lifestyle pattern of the patient.

30. The system according to claim 21 wherein the processor is further programmed to weigh the bG measurement if collection of the bG measurement was within a time interval from the daily times specified by the structured sampling schema.

31. The system according to claim 30 wherein the time interval is at most ±

50 minutes.

32. The system according to claim 21 wherein the processor is further programmed to determine the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements if a predetermined amount of the bG measurements per each of the daily times and the events has been collected.

33. The system according to claim 21 wherein the processor is further programmed to determine the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements if the collection of the bG measurements occurred within a predetermined period.

34. The system according to claim 21 wherein the processor is further programmed to determine the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements if a predetermined amount of the bG measurements per each of the daily times and the events has been collected, and if the collection of the bG measurements occurred within a predetermined period.

35. The system according to claim 21 wherein the weighting is based on both duration between meals and age of bG measurements.

36. The system according to claim 21 wherein the weighting is based on harmonic temporal weighting.

37. The system according to claim 21 wherein the collected bG measurements older than 120 days have a weight of zero.

38. The system according to claim 21 wherein the estimated true mean bG value ( bG) is determined by the processor solving and averaging mean bG values for the daily times, each being defined according to:

39. The system according to claim 21 wherein the estimate HbA1C value is determined by the processor solving the equation:

0.033 bG+0.5702, where bG is the estimated true mean bG value.

40. The system according to claim 38 wherein the estimate HbA1C value is determined by the processor solving the equation:

0.033 bG+0.5702, where bG is the estimated true mean bG value.

41. The system according to claim 21 wherein the processor is further programmed to provide alerts to signal the daily times and the events.

42. The system according to claim 21 wherein the processing is further programmed to provide a mode for entering lifestyle related parameters needed to determine the daily times and the events specified by the structured sampling schema.

43. A system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements comprising:

a blood glucose monitoring meter having memory and a first processor programmed to collect both bG measurements and associated context of the bG measurement at daily times specified by a structured sampling schema provided in the memory; and

a computer having a display, memory and a second processor programmed;

to receive the collected bG measurements and associated context from the meter;

to weight each of the collected bG measurements based on the associated context;

to determine the estimated true mean bG value and the estimate HbA1C value from the weighted measurements of the collected bG measurements; and

to provide the estimated true mean bG and the estimate HbA1C values to the display.

44. The system according to claim 43 wherein the meter includes a scheduler which prompts for the bG measurement and the associated context at the daily times specified by the structured sampling schema.