METHODS FOR THE PREVENTION AND TREATMENT OF BURN INJURIES AND SECONDARY COMPLICATIONS
First Claim
1. A method for treating a subject suffering from a burn injury or a systemic injury or condition secondary to a burn, the method comprising administering to the subject in need thereof an effective amount of a peptide having the formula D-Arg-2′
- 6′
-dimethyltyrosine-Lys-Phe-NH2.
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Accused Products
Abstract
The disclosure relates to methods for treating a subject suffering from a burn injury or associated complications by administering to the subject an effective amount of an aromatic-cationic peptide. For example, a burn injury may be associated with distant pathophysiological effects, such as hypermetabolism, skeletal muscle dysfunction, and organ damage. The disclosure also relates to methods for protecting a subject from a burn injury by administering an effective amount of an aromatic-cationic peptide to a subject at risk of a burn injury.
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Citations
20 Claims
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1. A method for treating a subject suffering from a burn injury or a systemic injury or condition secondary to a burn, the method comprising administering to the subject in need thereof an effective amount of a peptide having the formula D-Arg-2′
- 6′
-dimethyltyrosine-Lys-Phe-NH2. - View Dependent Claims (2, 3, 4, 5, 6, 9, 13, 14)
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- 7. The method of claim 7, wherein the peptide is administered following a burn injury but prior to the onset of symptoms of hypermetabolism.
- 10. The method of claim 10, wherein the skeletal muscle dysfunction is skeletal muscle wasting or cachexia.
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15. A method for protecting the subject against a burn injury, the method comprising administering to the subject in need thereof an effective amount of a peptide having the formula D-Arg-2′
- 6′
-dimethyltyrosine-Lys-Phe-NH2 prior to a burn injury. - View Dependent Claims (16)
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17. The method of claim 21, wherein the burn injury is a sunburn or radiation burn.
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18. A method for treating a disease or condition characterized by a reduced ATP synthesis rate, the method comprising administering to a mammal in need thereof an effective amount of a peptide having the formula D-Arg-2′
- 6′
-dimethyltyrosine-Lys-Phe-NH2 in order to increase the ATP synthesis rate in the subject. - View Dependent Claims (19, 20)
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Specification