Intranasal Opioid Compositions
First Claim
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1. A pharmaceutical composition for intranasal administration to a mammal;
- comprising;
an effective amount of an opioid;
a liquid nasal carrier for the opioid; and
one or more sweeteners, flavoring agents, or masking agents or combinations thereof.
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Abstract
The present invention relates to pharmaceutical compositions for intranasal administration to a mammal that contain an effective amount of an opioid, a liquid nasal carrier for the opioid, and optionally a sweetener, flavoring agent or masking agent. In some embodiments of the present invention, the pharmaceutical compositions have improved bioavailability. In other embodiments of the present invention, the opioid compositions improve patient compliance.
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Citations
25 Claims
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1. A pharmaceutical composition for intranasal administration to a mammal;
- comprising;
an effective amount of an opioid;
a liquid nasal carrier for the opioid; and
one or more sweeteners, flavoring agents, or masking agents or combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- comprising;
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11. A pharmaceutical composition having improved bioavailability for intranasal administration to a mammal;
- comprising;
an effective amount of butorphanol;
a preservative-free liquid nasal carrier. - View Dependent Claims (12, 13, 14, 15, 16, 22)
- comprising;
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17. A pharmaceutical composition having improved bioavailability for intranasal administration to a mammal;
- comprising;
an effective amount of hydromorphone;
a liquid nasal carrier having the essential absence of a preservative and the composition containing at least one sweetener, flavoring agent or masking agent. - View Dependent Claims (20)
- comprising;
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18. A pharmaceutical composition for intranasal administration to a mammal;
- comprising;
an effective amount of hydromorphone;
a preservative-free liquid nasal carrier comprising sodium chloride, citric acid, water and at least one sweetener, flavoring agent or masking agent. - View Dependent Claims (19, 21, 23)
- comprising;
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24. A method of treating a mammal suffering from pain comprising intranasally administering to the mammal an effective amount of butorphanol or hydromorphone;
- a preservative-free liquid nasal carrier comprising sodium chloride, citric acid, water and at least one sweetener, flavoring agent or masking agent.
- View Dependent Claims (25)
Specification