FOAMABLE ALCOHOL COMPOSITIONS, SYSTEMS AND METHODS OF USE

• US 20100331411A1
• Filed: 09/09/2010
• Published: 12/30/2010
• Est. Priority Date: 06/13/2005
• Status: Abandoned Application

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Asmus, Robert A.
• Application Number:
  US12/878,786
• Publication Number:
  US 20100331411A1
• Time in Patent Office: Days
• US Class Current: 514/552
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 8/894 modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: C11D 1/82 Compounds containing silicon
• CPC Class Codes: C11D 3/0094 High foaming compositions
• CPC Class Codes: C11D 3/2006 Monohydric alcohols
• CPC Class Codes: C11D 3/201 linear
• CPC Class Codes: C11D 3/225 etherified, e.g. CMC
• CPC Class Codes: C11D 3/3707 Polyethers, e.g. polyalkyleneoxides
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises:

• • (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
  • (B) Surfactant comprising a dimethicone surfactant; and
  • (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.

Claims

1. A non-aerosol foamable composition, comprising:

(A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight;

(B) a dimethicone surfactant selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol lactate, dimethicone copolyol adipate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and

combinations of two or more of the foregoing; and

(C) a component selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cetyl hydroxyethyl cellulose, ethylhydroxy ethyl cellulose, hydroxypropyl guar, polyglycerol, polyoxamer having a molecular weight of at least 100,000, polyoxamine, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-9, polyquaternium-11 to polyquaternium-47, polyvinyl methyl ether, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing;

wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 50 cps at 23°

C.; and

wherein the foamable composition forms a foam that maintains a measurable height for at least 5 seconds following creation of the foam.

2. The composition of claim 1 which demonstrates a percentage foam volume increase of at least 100%.

3. The composition of claim 1 wherein the viscosity of the composition prior to foaming at 23°

C. is within the range from about 0.5 cps to about 50 cps.

4. The composition of claim 1 wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 20 cps at 23°

C.

5. The composition of claim 4 wherein the viscosity of the composition prior to foaming at 23°

C. is within the range from about 0.5 cps to about 20 cps.

6. The composition of claim 1 wherein the foam is formed from the foamable composition without the use of a propellant when shaken or dispensed from a dispenser.

7. The composition of claim 1 wherein the component (C) is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, ethylhydroxy ethyl cellulose, polyoxamer, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylic acid, polyquaternium-2, polyquaternium-4, polyquaternium-11, polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-44, polyquaternium-46, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing.

8. The composition of claim 1 wherein the component (C) is a homopolymer or copolymer containing N-vinyl lactam monomeric units selected from the group consisting of N-vinyl-2-pyrrolidone, N-vinyl-2-valerolactam, N-vinyl-2-caprolactam, and mixtures of any of the foregoing, and optionally one or more comonomers selected from the group consisting of N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-1-propane sulfonic acid or its salt, vinyl acetate, and mixtures of any of the foregoing.

9. The composition of claim 1 wherein the component (C) is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, polyethylene-polypropylene copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, and combinations of two or more of the foregoing.

10. The composition of claim 1 wherein the monohydric alcohol is selected from the group consisting of ethanol, propanol, butanol, and combinations of two or more of the foregoing.

11. The composition of claim 1 wherein the monohydric alcohol is present in the composition at a concentration from about 60% to about 80% by weight.

12. The composition of claim 1 wherein the surfactant is present in the composition at a concentration from about 0.1% to about 10% by weight.

13. The composition of claim 12 wherein the surfactant is present in the composition at a concentration from about 0.5% to about 5% by weight.

14. The composition of claim 1 wherein the component (C) is present in the composition at a concentration between about 0.001% and about 5% by weight.

15. The composition of claim 1 wherein the component (C) is present in the composition at a concentration less than or equal to about 0.5% by weight.

16. The composition of claim 15 wherein the component (C) is present in the composition at a concentration less than or equal to about 0.1% by weight.

17. The composition of claim 16 wherein the component (C) is present in the composition at a concentration of about 0.06% by weight.

18. The composition of claim 1 wherein the dimethicone surfactant is selected from hydroxy-terminated dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, or combination of two or more of the foregoing.

19. The composition of claim 1 further comprising an emollient wherein the emollient is present in the composition at a concentration of about 30% by weight or less.

20. The composition of claim 1 further comprising an antifungal agent.

21. The composition of claim 1 further comprising an antimicrobial agent, present in the composition at a concentration up to about 10% by weight.

22. The composition of claim 21 wherein the antimicrobial agent is selected from the group consisting of parachlorometaxylenol, triclosan, chlorhexidine and its salts, polyhexamethylene biguanide and its salts, iodine, idodophors, fatty acid monoesters, poly-n-vinyl pyrrolidone-iodophors, silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing.

23. The composition of claim 22 wherein the antimicrobial agent is benzoyl peroxide.

24. The composition of claim 1 further comprising one or more skin barrier materials in an amount from about 0.1% to 60% by weight.

25. The composition of claim 24 wherein the barrier material is selected from the group consisting of aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose, cholecalciferol, cocoa butter, cod liver oil, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin, live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate, racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate, zinc oxide and combinations of two or more of the foregoing.

26. A system comprising:

a dispenser comprising a reservoir and a hand pump; and

the foamable composition of claim 1 contained within the reservoir.

27. A method for sanitizing a surface, comprising:

applying a volume of a non-aerosol foamable composition accordinig to present claim 1 to a surface, which upon shaking or dispensing from a dispenser forms a foam with a percentage foam volume increase of at least 100%, wherein the composition does not include a propellant, and the foam formed maintains a measurable height for at least 5 seconds following creation of the foam.

28. The method of claim 27 wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 20 cps at 23°

C.

29. The method of claim 27 wherein the surface is human skin.

30. The method of claim 27 wherein a discrete volume of stable foam is applied to the surface of the skin and subsequently spread out across the surface of the skin.

31. The method as defined in claim 30 further comprising rinsing the surface of the skin with water.

32. A non-aerosol foamable composition comprising:

(A) at least 55% by weight of a monohydric alcohol selected from the group consisting of C₂ to C₄ alcohols and combinations of two or more of the foregoing, based on the total weight of the composition;

(B) a dimethicone surfactant selected from the group consisting of PEG/PPG-4/12 dimethicone, PEG/PPG-35/65 dimethicone, PEG/PPG-18/18 dimethicone, hydroxy-terminated PEG-12 dimethicone, hydroxyl-capped dimethicone copolyol, Silicone Quaternary 1, Silicone Quaternary 2, dimethicone copolyol laurate, silicone copolyol pelargonate, dimethicone copolyol lactate, sodium dimethicone copolyol acetyl methyltaurate, PEG/PPG-17/18 dimethicone, silicone copolyol isostearate, methoxy-terminated PEG dimethicone, methoxy-terminated EO/PO dimethicone, hydroxypropyl methyl EO/PO dimethicone copolyol, butoxy-terminated PPO dimethicone, hydroxy-terminated PEG dimethicone, Polysilicone-8, and combinations thereof; and

(C) a component selected from the group consisting of ethylcellulose, PEG-150 pentaerythrityl tetrastearate, PEG-6 capric/caprylic glycerides, hydroxypropyl guar, butylated polyvinyl pyrrolidone, cetyl hydroxyethylcellulose, polyvinyl pyrrolidone, ethylene oxide/propylene oxide block copolymers, poly(ethylene oxide), poly(ethylene oxide, propylene oxide) monoallyl ether acetate, polyether polyol acetate, polyethylene oxide monoallyl ether, polyethylene glycol monoallyl ether acetate, and combinations thereof.

33. The composition of claim 32 further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof.

34. A non-aerosol foam comprising:

(A) at least 55% by weight of a monohydric alcohol selected from the group consisting of C₂ to C₄ alcohols and combinations of two or more of the foregoing, based on the total weight of the foam;

(B) a dimethicone surfactant selected from the group consisting of PEG/PPG-4/12 dimethicone, PEG/PPG-35/65 dimethicone, PEG/PPG-18/18 dimethicone, hydroxy-terminated PEG-12 dimethicone, hydroxyl-capped dimethicone copolyol, Silicone Quaternary 1, Silicone Quaternary 2, dimethicone copolyol laurate, silicone copolyol pelargonate, dimethicone copolyol lactate, sodium dimethicone copolyol acetyl methyltaurate, PEG/PPG-17/18 dimethicone, silicone copolyol isostearate, methoxy-terminated PEG dimethicone, methoxy-terminated EO/PO dimethicone, hydroxypropyl methyl EO/PO dimethicone copolyol, butoxy-terminated PPO dimethicone, hydroxy-terminated PEG dimethicone, Polysilicone-8, and combinations thereof; and

(C) a component selected from the group consisting of ethylcellulose, PEG-150 pentaerythrityl tetrastearate, PEG-6 capric/caprylic glycerides, hydroxypropyl guar, butylated polyvinyl pyrrolidone, cetyl hydroxyethylcellulose, polyvinyl pyrrolidone, ethylene oxide/propylene oxide block copolymers, poly(ethylene oxide), poly(ethylene oxide, propylene oxide) monoallyl ether acetate, polyether polyol acetate, polyethylene oxide monoallyl ether, polyethylene glycol monoallyl ether acetate, and combinations thereof.

35. The foam of claim 34 further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof.

36. A non-aerosol foamable composition comprising:

at least 60% by weight of ethanol, based on the weight of the composition;

water;

isopropanol;

a polymer of dimethylsiloxane with polyoxyethylene;

at least one of polyquaternium-1 to polyquaternium-47;

glycerol;

propylene glycol;

fragrance;

butylparaben;

ethylparaben;

methylparaben;

phenoxyethanol; and

propylparaben.

37. The non-aerosol foamable composition of claim 36 further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof.

38. The non-aerosol foamable composition of claim 36 further comprising a short chain alkyl or aryl ester (C₁-C₆) of a long chain straight or branched chain alkyl or alkenyl alcohol or acid (C₈-C₃₂) or its polyethoxylated derivative.

39. A non-aerosol foam comprising:

at least 60% by weight of ethanol, based on the weight of the foam;

water;

isopropanol;

a polymer of dimethylsiloxane with polyoxyethylene;

at least one of polyquaternium-1 to polyquaternium-47;

glycerol;

propylene glycol;

fragrance;

butylparaben;

ethylparaben;

methylparaben;

phenoxyethanol; and

propylparaben.

40. The non-aerosol foam of claim 39 further comprising a salt, an antimicrobial, a skin conditioning agent, a therapeutic agent, or a combination thereof.

41. The non-aerosol foam of claim 40 further comprising a short chain alkyl or aryl ester (C₁-C₆) of a long chain straight or branched chain alkyl or alkenyl alcohol or acid (C₈-C₃₂) or its polyethoxylated derivative.