Process for Preparation of Sevelamer Carbonate
First Claim
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1. A process for preparation of carbonate salt of amine polymers comprising interacting allylamine compound with suitable carbonate source.
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Abstract
The present invention discloses simple process for preparation of salt of polyallylamine polymer.
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47 Claims
- 1. A process for preparation of carbonate salt of amine polymers comprising interacting allylamine compound with suitable carbonate source.
- 13. A process for drying carbonate salt of amine polymers.
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20. A process for preparation of Sevelamer carbonate comprising
a) making polyallylamine from polyallylamine hydrochloride using suitable base b) treating polyallylamine with suitable carbonate source to get polyallylamine carbonate c) subjecting to crosslinking the obtained polyallylamine carbonate with suitable crosslinking agent optionally in presence of emulsifier and/or surfactant to get Sevelamer carbonate
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29. Carbonate salt of amine polymer having carbonate content from about 3 to about 7 meq/gm, Phosphate Binding Capacity of about 3 to about 7 mmol/gm and chloride content not more than 0.05%, residue on ignition not more than 0.1% and loss on drying not more than 10%.
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30. Sevelamer carbonate having less than 0.05% chloride content.
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31. The process for preparation of Sevelamer carbonate comprising
a) treating allylamine with suitable carbonate source to get allylamine carbonate; -
b) converting the obtained allylamine carbonate into polyallylamine carbonate; c) crosslinking obtained polyallylamine carbonate with crosslinking agent optionally in presence of emulsifier/surfactant; d) isolating Sevelamer carbonate - View Dependent Claims (32, 33, 34)
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- 35. A process for preparation of Sevelamer carbonate comprising contacting Sevelamer hydrochloride with suitable carbonate source.
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44. A process for preparation of Sevelamer carbonate comprising contacting Sevelamer hydrochloride with suitable base to get Sevelamer base and treating obtained Sevelamer base with suitable carbonate source to get Sevelamer carbonate.
Specification