Unit Dose Drug Delivery Platform
First Claim
1. A drug delivery system comprising:
- a housing configured to contain one or more crushable unit dosage forms;
a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the activation mechanism provides a mechanical advantage, a mechanical disadvantage or a combination of mechanical advantage and disadvantage to the activation mechanism; and
a discharge port formed in or contiguous with the housing and configured to release the contents of a dosage form upon activation of the activation mechanism.
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Accused Products
Abstract
The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.
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Citations
49 Claims
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1. A drug delivery system comprising:
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a housing configured to contain one or more crushable unit dosage forms; a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the activation mechanism provides a mechanical advantage, a mechanical disadvantage or a combination of mechanical advantage and disadvantage to the activation mechanism; and a discharge port formed in or contiguous with the housing and configured to release the contents of a dosage form upon activation of the activation mechanism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. An ophthalmic drug delivery system comprising:
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a housing configured to contain one or more crushable unit dosage forms; a user activation mechanism, effective when activated, to engage a drug delivery mechanism comprising a piston drivable into at least one dosage form contained in the housing, wherein the activation mechanism provides a mechanical advantage, a mechanical disadvantage or a combination of mechanical advantage and disadvantage to the activation mechanism; a discharge port formed in or contiguous with the housing and configured to release the contents of a dosage form upon activation of the activation mechanism; and an eye cup attached to the housing disposed to direct the contents of the dosage form into the eye of a recipient. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A drug delivery system comprising:
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a housing; a button on a surface of the housing and pivotable indexing lever that acts as a cover and an indexing lever from a closed position to a dispense position; a firing mechanism comprising a piston connected to a link contained in the housing and in contact with the button through the link; a discharge port attached to the housing and in fluid communication with a unit dosage form dispensing position in the housing; and a feed mechanism for a blister strip contained in the housing, and comprising a feed wheel, an indexing wheel, and a take-up wheel, effective to sequentially move unit dosage forms contained on the blister strip into dispensing position in front of the discharge port by turning the indexing wheel; wherein when the dispensing button is in the raised position, depressing the button forces the piston into an unit dosage form in the dispensing position, thereby forcing the contents of the unit dosage form through the discharge port into the eye, and wherein the link provides a mechanical advantage to the piston. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49)
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Specification