TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION

• US 20100331807A1
• Filed: 08/31/2010
• Published: 12/30/2010
• Est. Priority Date: 05/24/2002
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Whitehurst, Todd K., McGivern, James P., McClure, Kelly H.
• Granted Patent: US 8,401,634 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula

Abstract

Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

Claims

1-22. -22. (canceled)

23. A method for treating a movement disorder of a patient, comprising:

applying a stimulus to a stimulation site of the patient in accordance with one or more stimulation parameters to increase neural activity of the stimulation site, wherein the stimulation site comprises one of a nucleus tractus solitarius, pallido-subthalamic tracts, and putamen to GPi fibers.

24. The method of claim 23, wherein the stimulus comprises an electrical current.

25. The method of claim 24, wherein the electrical current has an amplitude in the range of 0.05 milliamps to 5.0 milliamps, and a frequency less than 100 Hertz.

26. The method of claim 23, wherein the stimulus comprises one or more drugs.

27. The method of claim 26, wherein the one or more drugs comprises at least one or more of an excitatory neurotransmitter, an excitatory cortical neurotransmitter agonist, an inhibitory neurotransmitter antagonist, an agent that increases the level of an excitatory neurotransmitter, and an agent that decreases the level of an inhibitory neurotransmitter.

28. The method of claim 23, further comprising:

sensing at least one condition related to the movement disorder; and

adjusting the one or more stimulation parameters based on the at least one sensed condition.

29. The method of claim 23, further comprising implanting a system control unit entirely within the brain of the patient, wherein the stimulus is generated by the system control unit.

30. The method of claim 23, further comprising storing the one or more stimulation parameters in a programmable memory unit.

31. The method of claim 23, wherein the stimulation site comprises the nucleus tractus solitarius.

32. The method of claim 23, wherein the stimulation site comprises the pallido-subthalamic tracts.

33. The method of claim 23, wherein the stimulation site comprises the GPi fibers.

34. A method for treating a movement disorder of a patient, comprising:

applying a stimulus to a stimulation site of the patient in accordance with one or more stimulation parameters to decrease neural activity of the stimulation site, wherein the stimulation site comprises one of pallido-thalamic axons, putamen to GPe fibers, and subthalamo-pallidal fibers.

35. The method of claim 34, wherein the stimulus comprises an electrical current.

36. The method of claim 35, wherein the electrical current has a frequency equal to or greater than 100 Hertz.

37. The method of claim 34, wherein the stimulus comprises one or more drugs.

38. The method of claim 34, further comprising:

sensing at least one condition related to the movement disorder; and

adjusting the one or more stimulation parameters based on the at least one sensed condition.

39. The method of claim 34, further comprising implanting a system control unit entirely within the brain of the patient, wherein the stimulus is generated by the system control unit.

40. The method of claim 34, further comprising storing the one or more stimulation parameters in a programmable memory unit.

41. The method of claim 34, wherein the stimulation site comprises the pallido-thalamic axons.

42. The method of claim 34, wherein the stimulation site comprises the putamen to GPe fibers.

43. The method of claim 34, wherein the stimulation site comprises the subthalamo-pallidal fibers.