Biphasic implant device providing joint fluid therapy

• US 20100331865A1
• Filed: 06/30/2009
• Published: 12/30/2010
• Est. Priority Date: 06/30/2009
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Inventors: Bradica, Gino, Ringeisen, Timothy A., Wattengel, William Christian
• Granted Patent: US 10,016,278 B2
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30014 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30031 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2002/30052 differing in electric or magnetic properties
• CPC Class Codes: A61F 2002/30088 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2002/30332 Conically- or frustoconically-shaped protrusion and recess
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/4495 having a fabric structure, e.g. made from wires or fibres
• CPC Class Codes: A61F 2210/008 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2250/0043 differing in electric properties, e.g. in electrical conductivity, in galvanic properties
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/48 : with macromolecular fillers
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 : Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Claims

1. A device for repair or replacement of tissue deficiencies, said device comprising at least two juxtaposed materials forming a malleable matrix capable of transmitting forces in the form of a vortex ring, with the first material presenting itself as a hydrogel capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading, said hydrogel encapsulating a second material in the form of a network of fibers, wherein stresses resulting from the dynamic loading are transmitted throughout the entire volume of the matrix by the fiber network, said force transmitted in the form of a three-dimensional vortex thereby accumulating desirable factors or molecules throughout the volume of the device.

2. The device of claim 1 wherein at least one of the materials is bioresorbable.

3. The device of claim 1 wherein the matrix is porous.

4. The device of claim 1 wherein the matrix becomes malleable upon hydration.

5. The device of claim 1 wherein the matrix returns to its original shape after deformation.

6. The device of claim 1 wherein the fiber material is suspended within the hydrogel material.

7. The device of claim 1 wherein the matrix also contains an additive in the form of a particulate or biologically active agent.

8. The device of claim 1 wherein the juxtaposed materials are selected from the groups consisting of ceramics, natural polymers, synthetic polymer and combinations thereof.

9. The device of claim 1 wherein the matrix is attached to a porous rigid base.

10. The device of claim 1 wherein the matrix is attached a rigid base material selected from the groups consisting of metals, polymers, ceramics or combinations thereof.

11. A device for repair or replacement of tissue deficiencies wherein the device is composed of at least two juxtaposed materials forming a malleable matrix capable of transmitting forces in the form of a gyre, wherein the first material is a collagen hydrogel capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading, said collagen hydrogel encapsulating a second material in the form of a network of collagen fibers wherein stresses resulting from the dynamic loading are transmitted throughout the entire volume of the matrix by the collagen fiber network, said force transmitted in the form of a three-dimensional vortex thereby accumulating desirable factors or molecules throughout the volume of the device.

12. A device for repair or replacement of tissue deficiencies wherein the device is composed of at least two juxtaposed materials forming a malleable matrix capable of transmitting forces in the form of a gyre, wherein the first material is a hyaluronic acid hydrogel capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading, said hyaluronic acid hydrogel encapsulating a second material in the form of a network of chitosan fibers wherein stresses resulting from the dynamic loading are transmitted throughout the entire volume of the matrix by the chitosan fiber network, said force transmitted in the form of a three-dimensional vortex thereby accumulating desirable factors or molecules throughout the volume of the device.