Inflatable Medical Device

• US 20100331947A1
• Filed: 02/16/2006
• Published: 12/30/2010
• Est. Priority Date: 02/17/2005
• Status: Abandoned Application

• Current Assignee: Alexander Dubson, Alon Shalev
• Original Assignee: Alexander Dubson, Alon Shalev
• Inventors: Shalev, Alon, Dubson, Alexander
• Application Number:
  US11/884,492
• Publication Number:
  US 20100331947A1
• Time in Patent Office: Days
• US Class Current: 623/1.11
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A medical device comprising a compartment capable of receiving and holding a substance in a liquid form is disclosed. The compartment is inflatable from a deflated state to an inflated state, such that when the compartment is in the deflated state, the outer wall of the membrane is substantially impermeable to the substance, and when the compartment is in the inflated state, the substance is allowed to permeate through the outer wall.

Claims

1. A medical device, comprising a compartment capable of receiving and holding a substance in a liquid form and having an outer wall;

said compartment being inflatable from a deflated state to an inflated state, such that when said compartment is in said deflated state, said outer wall is substantially impermeable to said substance, and when said compartment is in said inflated state, said substance is allowed to permeate through said outer wall out of said compartment.

2. The device of claim 1, wherein said outer wall is made, at least in part, of non-woven polymer fibers.

3. The device of claim 1, wherein said outer wall is made, at least in part, of a perforated film coated by a low strength membrane and/or soluble material.

4. An endoscopic system, comprising a catheter having a lumen and the medical device of claim 1 mounted on said catheter such that said lumen is in fluid communication with said compartment.

5. The system of claim 4, further comprising a pumping device for delivering said substance in said liquid form through said lumen to inflate said compartment.

6. A method of treating an artery, comprising:

(a) delivering the medical device of claim 1 to a location in the artery;

(b) inflating said compartment so as to widen the artery and deliver said substance between an arterial wall and said compartment; and

(c) deflating said compartment.

7. The method of claim 6, wherein said step (b) is effected by delivering said substance in said liquid form to said compartment at a sufficient pressure to inflate said compartment.

8. The method of claim 7, further comprising repeating said step (b) using a second substance being capable or reacting with the previously delivered substance.

9. The method of claim 6, further comprising repeating said steps (a)-(b) using a different compartment having therein a second substance being capable or reacting with the previously delivered substance.

14. The device of claim 1 wherein said compartment comprises a plurality of chambers.

15. The device of claim 14, wherein at least a few chambers of said plurality of chambers are generally concentric.

16. The device of claim 14, wherein at least a few chambers of said plurality of chambers are arranged in a generally longitudinal arrangement.

17. The device of claim 14, wherein at least a few chambers of said plurality of chambers are arranged in a generally lateral arrangement.

18. The device of claim 14, wherein at least a few chambers of said plurality of chambers contain different substances.

19. The device of claim 1 comprising said substance.

20. The device of claim 19, wherein said compartment comprises a plurality of chambers.

21. The device of claim 20, wherein at least a few chambers of said plurality of chambers contain different substances.

22. The device of claim 20, wherein at least one chamber of said plurality of chambers contains a contrast agent.

23. The device of claim 21, wherein at least two of said different substances are contained in adjacent chambers separated by a semi-preamble membrane, such that when said compartment is in said inflated state, the pressure in said adjacent chambers increases and said substances mix by permeating through said semi-preamble membrane to thereby form a third substance.

24. The device of claim 1 wherein said substance is capable of forming a rigid structure outside said compartment.

25. The device of claim 1 wherein said substance is polymerizable.

26. The device of claim 25, wherein said substance is polymerizable under physiological conditions.

27. The device of claim 1 wherein said substance comprises a polymerization initiator.

28. The device of claim 1 wherein said substance comprises an isomerization initiator.

29. The device of claim 1 wherein said substance comprises a cross-linking agent.

30. The device of claim 1 wherein said substance comprises a chemical hardening agent.

31. The device of claim 1 wherein said substance comprises a medicament.

32. The device of claim 1 wherein said outer wall of said compartment comprises at least one region which is substantially impermeable to said substance at all times.

33. The device of claim 1, wherein said compartment is adapted for mounting on a catheter.

34. The device of claim 1, wherein said compartment is shaped as a balloon and adapted for introduction into a body passageway.

35. The device of claim 4 wherein said compartment is designed and constructed such that when said compartment is in said inflated state, said outer wall of said compartment engages an inner wall of said body passageway and said substance contacts said inner wall.

36. The device of claim 1, wherein said compartment is adapted for introduction into a blood vessel.

37. The device of claim 1, further comprising a vascular prosthesis, wherein said compartment is disposed within said vascular prosthesis.

38. The device of claim 37, wherein at least a part of said vascular prosthesis is made of a material capable of hardening upon contacting said substance.

47. The device of claim 37, wherein said compartment is designed and constructed such that when said compartment is in said inflated state, said outer wall of said compartment engages an inner wall of said vascular prosthesis and said substance contacts said polymer to thereby harden said polymer.

48. The device of claim 1, further comprising an extendable tubular support structure, wherein said compartment is disposed within said extendable tubular support structure.

49. The device of claim 48, wherein said support structure is made of a material capable of hardening upon contacting said substance.

50. The device of claim 49, wherein said compartment is designed and constructed such that inflation of said compartment results in a radial extension of said support structure, permeation of said substance through said outer wall of said compartment, and hardening of said polymer via contact between said substance and said support structure.

10. A vascular prosthesis made of a material capable of hardening upon contacting a substance.

42. The vascular prosthesis of claim 10 wherein said vascular prosthesis comprises at least two layers.

43. The vascular prosthesis of claim 10 wherein said vascular prosthesis is a furcated vascular prosthesis.

44. The vascular prosthesis of claim 43, wherein said vascular prosthesis is a bifurcated vascular prosthesis.

45. The vascular prosthesis of claim 43, wherein said vascular prosthesis is a trifurcated vascular prosthesis.

46. The vascular prosthesis of claim 43, wherein said vascular prosthesis is a quadrifurcated vascular prosthesis.

11. A method of bypassing a blood vessel being at least partially occluded, comprising:

providing a vascular prosthesis having said compartment disposed therein, wherein at least a part of said vascular prosthesis is made of a material capable of hardening upon contacting said substance;

using said vascular prosthesis for establishing direct fluid communication between an upstream vascular location being upstream an occlusion in the blood vessel and a downstream vascular location being downstream said occlusion;

inflating said compartment so as so as to release said substance to contact said vascular prosthesis, thereby hardening said vascular prosthesis; and

deflating said compartment.

13. The method of claim 11 wherein said inflating said compartment is effected by delivering said substance in said liquid form to said compartment at a sufficient pressure to inflate said compartment.

39. The device of claim 11 wherein at least a part of said vascular prosthesis is made of non-woven polymer fibers.

40. The device of claim 39, wherein at least a portion of said non-woven polymer fibers is made of a material capable of hardening upon contacting said substance.

41. The device of claim 39, wherein said non-woven polymer fibers form a matrix having pores, and wherein said pores are filled with a material capable of hardening upon contacting said substance.

12. A method of replacing a portion of a blood vessel, comprising:

providing a vascular prosthesis having said compartment disposed therein;

excising the portion of the blood vessel, thereby creating a pair of blood vessel ends;

connecting said vascular prosthesis to said pair of blood vessel ends so as to allow blood flow through said vascular prosthesis;

inflating said compartment so as so as to release said substance to contact said vascular prosthesis, thereby hardening said vascular prosthesis; and

deflating said compartment.