Biphasic implant device transmitting mechanical stimulus

• US 20100331979A1
• Filed: 06/30/2009
• Published: 12/30/2010
• Est. Priority Date: 06/30/2009
• Status: Abandoned Application

• Current Assignee: Kensey Nash Corporation (DSM-Firmenich AG)
• Original Assignee: Kensey Nash Corporation (DSM-Firmenich AG)
• Inventors: McDade, Robert L., Ringeisen, Timothy A.
• Application Number:
  US12/495,688
• Publication Number:
  US 20100331979A1
• Time in Patent Office: Days
• US Class Current: 623/14.12
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30014 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2002/30028 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30031 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2002/30052 differing in electric or magnetic properties
• CPC Class Codes: A61F 2002/30088 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2002/30332 Conically- or frustoconically-shaped protrusion and recess
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/4495 having a fabric structure, e.g. made from wires or fibres
• CPC Class Codes: A61F 2210/008 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2250/0043 differing in electric properties, e.g. in electrical conductivity, in galvanic properties
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/48 : with macromolecular fillers
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 : Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

Claims

1. A multiphasic device for repair or replacement of articular cartilage and the underlying bone, said device comprising a bone region and a malleable cartilage region said bone region comprising a porous material and a rigid penetrating force conductive material for conducting pressure forces experienced by said cartilage region through said bone region and into said external underlying bone tissue, thereby preventing bone tissue loss in said external underlying bone tissue.

2. The device of claim 1 wherein the pressure forces are conducted as hydrostatic pressure pulses along rigid conductive elongated channels running through the porous material of the bone phase and radiating out and away from the cartilage phase.

3. The device of claim 1 wherein the rigid conductive material is in the form of one or more vertical rigid columns oriented perpendicular to the top and bottom surfaces that flare out as they reach the underlying external bone, said vertical rigid columns transforming the fluid forces into kinetic pressure pulses that are carried through the porous material and into the underlying bone.

4. The device of claim 1 wherein the rigid conductive material is a rigid multi-facetted web structure oriented perpendicular to the top and bottom surfaces, said web structure transferring the fluid forces into kinetic pressure pulses that are carried through the porous material and into the underlying bone.

5. The device of claim 1 wherein the rigid conductive material is in the form of one or more vertical rigid cones or wedges oriented perpendicular to the top and bottom surfaces with the base located towards the cartilage phase, said vertical rigid columns transforming the fluid forces into kinetic pressure pulses that are carried through the porous material and into the underlying bone while at the same time applying an outward force to the porous material.

6. The device of all the above claims wherein the rigid conductive material extends partially into the malleable cartilage phase.

7. The device of all the above claims wherein the rigid conductive material extends partially into the external underlying bone.

8. The device of all the above claims wherein at least one of the materials is bioresorbable

9. The device of all the above claims wherein the rigid conductive material is porous.

10. The device of all the above claims wherein the rigid conductive material is selected from the groups consisting of metals, ceramics, polymers, glasses, or combinations thereof.

11. The device of all the above claims wherein the porous material is a polymer.

12. The device of all the above claims wherein the porous material contains an additive in the form of a particulate or biologically active agent.

13. The device of all the above claims wherein the rigid conductive material contains an additive in the form of a particulate or biologically active agent.

14. A multiphasic device for repair or replacement of articular cartilage and the underlying bone, said multiphasic device comprising a bone region and a malleable cartilage region, said bone region comprising at least a first material in the form of at least two porous rigid scaffolds separated by at least a second material in the form of a malleable elastic hydrogel, said hydrogel being capable of transferring hydrostatic pressure pulses through the bone region, said bone region preventing bone voids from forming in external underlying bone tissue by conducting pressure forces experienced in said malleable cartilage phase through said bone region and into said underlying bone tissue.

15. The multiphasic device of claim 14 wherein the porous rigid materials are in the form of disks having a thickness of 1000 microns to 4000 microns, separated by a hydrogel having a thickness of no less that 5 microns.

16. The multiphasic device of claim 14 wherein the porous rigid materials are in the form of porous particles having an approximate diameter in the range of 1000 microns to 4000 microns, suspended in a hydrogel, and separated from each other by no less than 5 microns.

17. The multiphasic device of claim 14 wherein at least one of the materials is bioresorbable.

18. The multiphasic device of claim 14 wherein the device becomes malleable upon hydration.

19. The device of claim 14 wherein the porous rigid material is selected from the groups consisting of metals, polymers, ceramics, glasses or combinations thereof.

20. The device of claim 14 wherein the matrix contains an additive in the form of a particle or biologically active agent.

21. The device claim 14 wherein the porous rigid material contains an additive in the form of a particulate or biologically active agent.

22. The device claim 14 wherein the hydrogel contains an additive in the form of a particulate or biologically active agent.