METHOD OF INSTALLING A TRANSCUTANEOUS PROSTHESIS

• US 20100331996A1
• Filed: 09/13/2010
• Published: 12/30/2010
• Est. Priority Date: 06/23/2000
• Status: Active Grant

• Current Assignee: University College London (University of London)
• Original Assignee: University College London (University of London)
• Inventors: Unwin, Paul, Cobb, Justin, Blunn, Gordon, Goodship, Allen
• Granted Patent: US 8,137,409 B2
• Time in Patent Office: Days
• US Class Current: 623/23.44
• CPC Class Codes: A61C 8/0006 Periodontal tissue or bone regeneration support means for endoprosthetic bone substitute or bone graft implants A61F2/2846
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0018 characterised by the shape
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/2814 Bone stump caps
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/54 Artificial arms or hands or parts thereof
• CPC Class Codes: A61F 2/60 Artificial legs or feet or parts thereof
• CPC Class Codes: A61F 2/78 Means for protecting prostheses or for attaching them to the body, e.g. bandages, harnesses, straps, or stockings for the limb stump
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue of bone tissue onto implantable joints A61F2002/30932
• CPC Class Codes: A61F 2002/30224 cylindrical
• CPC Class Codes: A61F 2002/30225 Flat cylinders, i.e. discs
• CPC Class Codes: A61F 2002/30322 differing in surface structures
• CPC Class Codes: A61F 2002/30558 Force-limiting means
• CPC Class Codes: A61F 2002/30561 breakable or frangible
• CPC Class Codes: A61F 2002/30574 with an integral complete or partial collar or flange
• CPC Class Codes: A61F 2002/30604 : modular
• CPC Class Codes: A61F 2002/30785 : parallel
• CPC Class Codes: A61F 2002/30838 : Microstructures
• CPC Class Codes: A61F 2002/30845 : with cutting edges
• CPC Class Codes: A61F 2002/30878 : with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
• CPC Class Codes: A61F 2002/30879 : Ribs
• CPC Class Codes: A61F 2002/30929 : having at least two superposed coatings
• CPC Class Codes: A61F 2002/3093 : for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2002/7887 : for connecting limb exoprostheses to the stump bone
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0026 : differing in surface structures
• CPC Class Codes: A61F 2250/0073 : Force-limiting means
• CPC Class Codes: A61F 2250/0074 : Torque-limiting means
• CPC Class Codes: A61F 2310/0058 : Coating made of diamond or of diamond-like carbon DLC
• CPC Class Codes: A61F 2310/00604 : Coating made of aluminium oxide or hydroxides
• CPC Class Codes: A61F 2310/00796 : Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
• CPC Class Codes: A61F 2310/00976 : Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
• CPC Class Codes: A61L 2430/02 : for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/28 : Materials for coating prostheses
• CPC Class Codes: A61L 27/303 : Carbon
• CPC Class Codes: A61L 27/34 : Macromolecular materials
• CPC Class Codes: C08L 89/00 : Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion. The method includes attaching the first component to a bone such that a transition from the second component to the third component is essentially at the surface of the skin and the third component extends from the skin surface when the first component is attached to a bone

Claims

1. A method of installing a transcutaneous prosthesis which comprises a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface, wherein the outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion, the method comprising:

attaching the first component to a bone such that a transition from the second component to the third component is essentially at the surface of the skin and the third component extends from the skin surface when the first component is attached to a bone.

2. The method according to claim 1, wherein the attaching step includes inserting the first component into a intramedullary canal of the bone.

3. The method according to claim 2, wherein the second component extends from an end of the bone to the surface of the skin when the first component is implanted in the bone.

4. The method according to claim 1, wherein prior to installing the prosthesis the skin is reduced in thickness.

5. The method according to claim 4, wherein the skin hypodermis is surgically removed.

6. The method of claim 1 wherein the components are integrally formed and have different surface treatments.

7. A method according to claim 1, wherein the first component has a surface treatment which stimulates bone growth and ossesous integration.

8. A method according to claim 1, wherein the second component has a micro-pitted surface.

9. A method according to claim 1, wherein the surface of the second component carries a protein coating.

10. A method according to claim 1, wherein the second component extends outwardly from the first and third components.

11. A method according to claim 10, wherein the second component has through-holes.

12. A method according to claim 1, where the third component carries a coating comprising a fluoro- or silicon polymer.

13. A method according to claim 1, wherein the third component carries a coating comprising diamond like carbon.

14. A method according to claim 1, wherein the third component includes a frangible or detachable linkage which permits an external component to detach in the event that an unusually high load is applied to the prosthesis.

15. A method according to claim 1, in which the third component is adapted for connection to an artificial limb or digit.

16. A method according to claim 9, wherein the protein coating is fibronectin or laminin.

17. A method according to claim 1, wherein the surface of the second component carries a hydrated calcium phosphate coating.

18. A method as claimed in claim 17, wherein the hydrated calcium phosphate coating is a coating of hydroxy apatite.

19. A method as claimed in claim 1, wherein the surface energy of the third component is a surface energy level of a non-stick material such as a fluoro or silicone polymer or diamond-like carbon.

20. A method as claimed in claim 1, wherein the outer surface of the third component has a coating of a non-stick material.

21. A method as claimed in claim 1, wherein the first component is shaped for implantation into a bone.

22. A method as claimed in claim 10, wherein the second component extends in an outward direction perpendicular to the first and third components.

23. A method according to claim 10, wherein the second component extends in an outward direction perpendicular to the first and third components, in plate like form.

24. A method according to claim 10, wherein the second component is mushroom shaped.

25. A method according to claim 11, wherein the second component has first set of through holes of a first size and a second set of through holes of a second size.