METHOD OF CLADDING MONOLITHIC SILICA BODY AND SEPARATION MEDIUM

• US 20110000279A1
• Filed: 02/01/2008
• Published: 01/06/2011
• Est. Priority Date: 02/01/2008
• Status: Active Grant

• Current Assignee: GL Sciences Incorporated
• Original Assignee: GL Sciences Incorporated
• Inventors: Ohira, Masayoshi, Furuno, Masahiro, Miyazaki, Shota, Terashima, Hiroyuki, Morisato, Kei, Nyudo, Masahiko
• Granted Patent: US 8,935,941 B2
• Time in Patent Office: Days
• US Class Current: 73/23.35
• CPC Class Codes: B01D 15/20 relating to the conditioning of the sorbent material
• CPC Class Codes: B01D 15/22 relating to the construction of the column
• CPC Class Codes: B01J 20/103 comprising silica
• CPC Class Codes: B01J 20/28042 Shaped bodies; Monolithic structures
• CPC Class Codes: B01J 20/283 based on silica
• CPC Class Codes: B01J 20/3257 the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 2220/54 Sorbents specially adapted for analytical or investigative chromatography
• CPC Class Codes: B01J 2220/82 Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
• CPC Class Codes: B01J 2220/825 comprising a cladding or external coating
• CPC Class Codes: G01N 2030/528 Monolithic sorbent material
• CPC Class Codes: G01N 30/50 Conditioning of the sorbent material or stationary liquid
• CPC Class Codes: G01N 30/6052 body

Abstract

To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.

Claims

1. A method of cladding a monolithic silica body, the method comprising providing a rod-shaped monolithic silica body, coating the monolithic silica body with a glass body having the same main component as the monolithic silica body, and fusing the monolithic silica body and the glass body at the melting temperature of the glass body at a predetermined pressure.

2. The method of cladding a monolithic silica body according to claim 1, wherein the side surface of the monolithic silica body and the glass body are fused at least in part.

3. The method of cladding a monolithic silica body according to claim 2, wherein the step of fusing the monolithic silica body and the glass body is flexibly controlled by temperature.

4. The method of cladding a monolithic silica body according to claim 3, wherein the side surface of the monolithic silica body is coated with the glass body, and then the monolithic silica body is subjected to chemical modification.

16. The method of cladding a monolithic silica body according to claim 1, wherein the side surface of the monolithic silica body is coated with the glass body, and then the monolithic silica body is subjected to chemical modification.

5. A method of cladding a monolithic silica body, the method comprising providing a rod-shaped monolithic silica body and coating the monolithic silica body with a glass body and then subjecting the monolithic silica body to chemical modification.

6. A separation medium prepared by coating a side surface of a rod-shaped monolithic silica body with glass having the same main component as the monolithic silica body and fusing the two.

7. The separation medium according to claim 6, wherein at least part of the side surface of the monolithic silica body is fused with glass.

8. A separation medium according to claim 6, wherein the monolithic silica body has been additionally subjected to chemical modification.

9. The separation medium according to claim 8, wherein an opening is formed on at least one end of the monolithic silica body.

10. The separation medium according to claim 9, wherein a protective layer is formed on the outside of the glass.

11. The separation medium according to claim 10, wherein a coat layer is provided between the outside of the glass and the protective layer.

12. The separation medium according to claim 10, wherein the protective layer comprises one member selected from metal and synthetic polymer or a mixture thereof.

13. The separation medium according to claim 12, wherein the coat layer contains a synthetic polymer.

14. The separation medium according to claim 6, wherein the separation medium is any one of an HPLC column, a GC column, a column for column chromatography, a column for pretreatment, a guard column, a cartridge for solid phase and a passive sampler.

15. A method of analysis, comprising using the separation medium according to claim 14.

17. The separation medium according to claim 6, wherein an opening is formed on at least one end of the monolithic silica body.

18. The separation medium according to claim 17, wherein a protective layer is formed on the outside of the glass.

19. The separation medium according to claim 6, wherein a protective layer is formed on the outside of the glass.

20. A method of analysis, comprising using the separation medium according to claim 6.