BISPECIFIC ANTIBODIES THAT BIND TO COMPLEMENT PROTEINS
First Claim
1. A bispecific antibody that binds to:
- (a) C5a and C5aR1;
(b) C5a and C5b;
(c) C5b and C5aR1;
(d) C5a and C5L2;
(e) C5b and C5L2;
(f) C5aR1 and C5L2;
(g) C5b-6 and C5a;
(h) C5b-6 and C5b;
(i) C5b-6 and C5aR1;
or (j) C5b-6 and C5L2.
1 Assignment
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Accused Products
Abstract
The present disclosure relates to bispecific antibodies that can bind to two or more different epitopes. For example, the bispecific antibodies described herein can bind to two or more different proteins, wherein at least two of the proteins are selected from C5a, C5b, a cellular receptor for C5a (e.g., C5aR1 or C5L2), the C5b-9 complex, and a component or intermediate of terminal complement such as C5b-6, C5b-7, or C5b-8. The bispecific antibodies described herein are useful for, e.g., inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9 complex) and/or C5a anaphylatoxin-mediated inflammation (e.g., C5a-mediated chemotaxis of inflammatory immune cells). Accordingly, the bispecific antibodies can be used in methods for treating a variety of complement pathway-associated disorders.
35 Citations
34 Claims
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1. A bispecific antibody that binds to:
- (a) C5a and C5aR1;
(b) C5a and C5b;
(c) C5b and C5aR1;
(d) C5a and C5L2;
(e) C5b and C5L2;
(f) C5aR1 and C5L2;
(g) C5b-6 and C5a;
(h) C5b-6 and C5b;
(i) C5b-6 and C5aR1;
or (j) C5b-6 and C5L2.
- (a) C5a and C5aR1;
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2. A bispecific antibody comprising at least two different antigen combining sites, wherein:
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(i) at least one antigen combining site binds to C5a and at least one antigen combining site binds to C5b or a cellular receptor for C5a; (ii) at least one antigen combining site binds to C5b and at least one antigen combining site binds to a cellular receptor for C5a; (iii) at least one antigen combining site binds to C5a or C5b and at least one antigen combining site binds to a cellular receptor for C5a; (iv) at least one antigen combining site binds to C5a, C5b, or a cellular receptor for C5a and at least one antigen combining site binds to C5b-6; (v) at least one antigen combining site binds to C5aR1 and at least one antigen combining site binds to C5L2;
or(vi) at least one antigen combining site binds to C5b, C5b-6, C6, C7, C8, or C9 and at least one antigen combining site binds to C5a or a cellular receptor for C5a. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification