Pharmacology of Visual Cycle Modulators
First Claim
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1. A method of treating an ophthalmic disease or disorder comprising administration of a non-retinoid compound resulting in a normalized electroretinogram response from about 5% to about 55% after about 12 hours to about 48 hours post administration of said non-retinoid compound.
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Abstract
Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.
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Citations
52 Claims
- 1. A method of treating an ophthalmic disease or disorder comprising administration of a non-retinoid compound resulting in a normalized electroretinogram response from about 5% to about 55% after about 12 hours to about 48 hours post administration of said non-retinoid compound.
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13. A method of treating an ophthalmic disease or disorder comprising administration of a single dose of a non-retinoid compound resulting in a greater normalized electroretinogram response on day 1 than on day 2.
- 14. A method of treating an ophthalmic disease or disorder comprising administration of a non-retinoid compound resulting in a greater therapeutic response on day 2 than on day 1 after the administration of a single dose.
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16. A method of treating an ophthalmic disease or disorder comprising administration of a non-retinoid compound resulting in a normalized electroretinogram response less than about 50% for a time period of about 4 hours to about 36 hours, about 4 hours to about 10 hours, about 10 hours to about 16 hours, about 16 hours to about 24 hours, or about 24 hours to about 36 hours after the plasma concentration of said non-retinoid compound has declined to 0.3 Cmax.
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37. A method of determining the dose to be administered for the treatment of an ophthalmic disease or disorder by administration of a non-retinoid visual cycle modulator comprising determining the normalized electroretinogram response from about 12 hours to about 48 hours after the administration of a single dose of said non-retinoid visual cycle modulator.
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38. A controlled-release solid dosage form for the treatment of an ophthalmic disease or disorder comprising a compound of Formula (I) wherein the plasma Tmax is observed 12 hours post-dose.
- 39. A dosing schedule for the treatment of an ophthalmic disease or disorder comprising a drug holiday after from about 3 months of continuous daily dosing to about 12 months of continuous daily dosing.
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Specification