METHOD FOR NON-INVASIVE ANALYSIS OF A SUBSTANCE CONCENTRATION WITHIN A BODY
First Claim
1. A method for non-invasive measurement of a concentration of a substance in a body, comprising the steps of:
- changing a temperature of a surface of a body from a first temperature to a second temperature;
changing the temperature of the surface of the body from the second temperature to the first temperature;
measuring a first amount of infrared radiation absorbed or emitted from a body in a first wavelength band at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature;
measuring a second amount of infrared radiation absorbed or emitted from a body in a second wavelength band at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature;
measuring a temperature at the surface of the body;
measuring an ambient temperature;
calculating a normalized ratio parameter based on the first amount, the second amount, the body surface temperature and the ambient temperature; and
determining the concentration of the substance in the body by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature.
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Accused Products
Abstract
Embodiments of the present methods measure a concentration of a substance, such as glucose, in a body. The described embodiments change the temperature of the surface of a body from a first temperature to a second temperature, then change the temperature of the surface of the body from the second temperature back to the first temperature, and measure a first amount of infrared (“IR”) radiation absorbed or emitted from the surface of the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the surface of the body in a second wavelength band at predetermined time intervals during the time period that the temperature of the surface of the body changes from the second temperature back to the first temperature. The described embodiments also measure a temperature at the surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is determined by correlating the normalized ration parameter with the body surface temperature and the ambient temperature.
31 Citations
18 Claims
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1. A method for non-invasive measurement of a concentration of a substance in a body, comprising the steps of:
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changing a temperature of a surface of a body from a first temperature to a second temperature; changing the temperature of the surface of the body from the second temperature to the first temperature; measuring a first amount of infrared radiation absorbed or emitted from a body in a first wavelength band at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature; measuring a second amount of infrared radiation absorbed or emitted from a body in a second wavelength band at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature; measuring a temperature at the surface of the body; measuring an ambient temperature; calculating a normalized ratio parameter based on the first amount, the second amount, the body surface temperature and the ambient temperature; and determining the concentration of the substance in the body by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of noninvasively measuring a concentration of a substance in a body using an apparatus including a detector and an optical system, the method comprising the steps of:
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changing a temperature of a surface of a body from a first temperature to a second temperature; changing the temperature of the surface of the body from the second temperature to the first temperature; detecting an infrared radiation value emitted by the body in a wavelength band including at least one wavelength characteristic of the substance at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature; and detecting an infrared radiation value emitted by the body in a wavelength band including at least one wavelength characteristic of the substance at predetermined time intervals during the change of the surface of the body from the second temperature to the first temperature. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification