DEVICE FOR INCREASING CEREBRAL BLOOD FLOW

• US 20110004158A1
• Filed: 04/29/2010
• Published: 01/06/2011
• Est. Priority Date: 11/02/2007
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: CS Therapeutics, Inc.
• Inventors: Moran, Timothy, Luciano, Mark G., Dombrowski, Stephen M.
• Granted Patent: US 9,011,378 B2
• Time in Patent Office: Days
• US Class Current: 604/131
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure
• CPC Class Codes: F04B 43/06 Pumps having fluid drive

Abstract

A device for regulating cerebrospinal fluid in a cerebrospinal fluid space includes a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid. An actively oscillatably changeable sealed fluid volume can be in fluid communication with the cerebrospinal conduit. The changeable sealed fluid volume can be in a sealed fluid path extending to the distal end of the cerebrospinal conduit and is capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space.

Claims

1. A device for regulating cerebrospinal fluid in a cerebrospinal fluid space comprising:

a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid; and

an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit and capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space.

2. The device of claim 1 further comprising an actuator coupled to the changeable sealed fluid volume for oscillating the changing fluid volume size of the changeable sealed fluid volume.

3. The device of claim 2 further comprising a sensor system for sensing conditions of a patient, the sensor system being in communication with the actuator for controlling operation of the actuator.

4. The device of claim 3 in which the sensor system includes a control system for controlling operation of the actuator.

5. The device of claim 4 in which the operation of the actuator is synchronized with a biorhythm of the patient.

6. The device of claim 5 in which the biorythm is related the patient'"'"'s heart.

7. The device of claim 5 in which the actuator is synchronized with a signal that is selected from the group consisting of an ECG signal, a pulse signal and a pressure signal.

8. The device of claim 4 in which the sensor system includes a sensor for sensing within the cerebrospinal fluid space for forming a feed back loop to control the level of cerebrospinal fluid within the cerebrospinal fluid space.

9. The device of claim 1 further comprising a fluid storage container coupled to the changeable sealed fluid volume and controllably fluidly isolated from the changeable sealed fluid volume.

10. The device of claim 1 in which the changeable sealed fluid volume includes a movable piston.

11. The device of claim 1 in which the changeable sealed fluid volume includes a bellows device.

12. The device of claim 2 in which the changeable sealed fluid volume includes a deformable fluid tight membrane on which the actuator is capable of applying an oscillating force for oscillating the changing fluid volume size of the changeable sealed fluid volume.

13. The device of claim 1 in which the changeable sealed fluid volume is within a container, the container having a deformable fluid tight membrane with a first surface that defines a boundary forming at least a portion of the changeable sealed fluid volume, the deformable membrane being capable of deforming to oscillate the changing fluid volume size of the changeable sealed fluid volume.

14. The device of claim 13 in which the deformable membrane has a second surface which is fluidly isolated from said first surface, whereby application of an oscillating force on the second surface of the deformable membrane is capable of deforming the deformable membrane to oscillate the changing fluid volume size of the changeable sealed fluid volume.

15. The device of claim 14 in which the container has a first port in communication with the changeable sealed fluid volume, the cerebrospinal conduit being coupled to the first port, the container also having a second port in communication with the second surface of the deformable membrane.

16. The device of claim 15 in which the deformable membrane is a diaphragm extending within the container.

17. The device of claim 15 in which the deformable membrane is a balloon positioned within the container.

18. The device of claim 15 further comprising an oscillating pump coupled to the second port of the container for providing oscillating fluid pressure to the second surface of the deformable membrane.

19. A device for regulating cerebrospinal fluid in a cerebrospinal fluid space comprising:

a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid; and

an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit and capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space;

an actuator coupled to the changeable sealed fluid volume for oscillating the changing fluid volume size of the changeable sealed fluid volume; and

a control system for controlling operation of the actuator synchronized with a biorythm.

20. A method of regulating cerebrospinal fluid in a cerebrospinal fluid space comprising:

inserting a distal end of a cerebrospinal conduit into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid;

coupling an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit; and

actively oscillating the changeable sealed fluid volume, the changeable sealed fluid volume oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space.

21. The method of claim 20 further comprising oscillating the changing fluid volume size of the changeable sealed fluid volume with an actuator coupled to the changeable sealed fluid volume.

22. The method of claim 21 further comprising sensing conditions of a patient with a sensor system, the sensor system being in communication with the actuator for controlling operation of the actuator.

23. The method of claim 22 further comprising controlling operation of the actuator with a control system associated with the sensor system.

24. The method of claim 23 further comprising operating the actuator in synchronization with a biorhythm of the patient.

25. The method of claim 24 further comprising relating the biorythm with the patient'"'"'s heart.

26. The method of claim 24 further comprising synchronizing the actuator with a signal selected from the group consisting of an ECG signal, a pulse signal and a pressure signal.

27. The method of claim 23 further comprising controlling the level of cerebrospinal fluid within the cerebrospinal fluid space with a sensor within the cerebrospinal fluid space that forms a feed back loop.

28. The method of claim 20 further comprising coupling a fluid storage container to the changeable sealed fluid volume, the fluid storage container being controllably fluidly isolated from the changeable sealed fluid volume.

29. The method of claim 20 further comprising oscillating the changing fluid volume size of the changeable sealed fluid volume with a movable piston.

30. The method of claim 20 further comprising oscillating the changing fluid volume size of the changeable sealed fluid volume with a bellows device.

31. The method of claim 21 in which the changeable sealed fluid volume includes a deformable fluid tight membrane, the method further comprising applying an oscillating force on the deformable membrane for oscillating the changing fluid volume size of the changeable sealed fluid volume.

32. The method of claim 20 in which the changeable sealed fluid volume is within a container, the container having a deformable fluid tight membrane with a first surface that defines a boundary forming at least a portion of the changeable sealed fluid volume, the method further comprising deforming the deformable membrane to oscillate the changing fluid volume size of the changeable sealed fluid volume.

33. The method of claim 32 in which the deformable membrane has a second surface which is fluidly isolated from said first surface, the method further comprising applying an oscillating force on the second surface of the deformable membrane for deforming the deformable membrane to oscillate the changing fluid volume size of the changeable sealed fluid volume.

34. The method of claim 33 in which the container has a first port in communication with the changeable sealed fluid volume, and a second port in communication with the second surface of the deformable membrane, the method further comprising coupling the cerebrospinal conduit to the first port.

35. The method of claim 34 further comprising extending a diaphragm within the container as the deformable membrane.

36. The method of claim 34 further comprising positioning a balloon within the container as the deformable membrane.

37. The method of claim 34 further comprising providing oscillating fluid pressure to the second surface of the deformable membrane with an oscillating pump coupled to the second port of the container.

38. Use of a device comprising:

a cerebrospinal conduit having a distal end for insertion into a cerebrospinal fluid space in fluid communication with a cerebrospinal fluid; and

an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit and capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space for regulating the cerebrospinal fluid in the cerebrospinal fluid space.