REDUCED RISK TOBACCO PRODUCTS AND USE THEREOF
First Claim
1. A cigarette comprising a blend of cured tobacco, wherein said blend comprises a Burley tobacco in an amount greater than about 50% by weight based on the combined weight of the blend of cured tobacco, wherein the cigarette is configured to produce a mainstream smoke that generates fewer DNA double strand breaks (DNA DSBs) in human cells than the mainstream smoke from a reference cigarette under the same smoking conditions.
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0 Petitions
Accused Products
Abstract
Reduced risk tobacco-related products and methods of use. These tobacco-related products (e.g., cigarettes or filters) are designed to reduce the biological insult, for example, DSBs, cell death or perturbation of RNA transcriptome or proteome as compared to the amount of biological insult induced by another cigarette, such as a conventional or reference cigarette (e.g., 2R4F), in human cells, and to provide a reduced risk cigarette that meets a cigarette smoker'"'"'s sensory/perception needs.
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Citations
38 Claims
- 1. A cigarette comprising a blend of cured tobacco, wherein said blend comprises a Burley tobacco in an amount greater than about 50% by weight based on the combined weight of the blend of cured tobacco, wherein the cigarette is configured to produce a mainstream smoke that generates fewer DNA double strand breaks (DNA DSBs) in human cells than the mainstream smoke from a reference cigarette under the same smoking conditions.
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26. A method of gradually reducing the exposure of a tobacco user to a toxicant that induces DNA double strand breaks (DNA DSBs) comprising:
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identifying the tobacco user to receive a gradual reduction in exposure to a toxicant that induces DNA DSBs in human cells; replacing a cigarette consumed by said identified tobacco user with a first cigarette for a predetermined length of time, wherein said first cigarette comprises a first cigarette filter that comprises a carbon or a weak base amine-containing resin; replacing the first cigarette with a second cigarette after said predetermined length of time, wherein said second cigarette comprises a second cigarette filter that comprises a carbon, or a weak base amine containing resin, wherein said second cigarette filter is configured to retain a greater amount of the toxicant that induces DNA DSBs in human cells than said first cigarette filter. - View Dependent Claims (27, 28)
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- 29. A cigarette filter comprising a carbon that has a total pore volume of from about 0.1 mL/g to about 0.9 mL/g in the cigarette filter.
Specification