Chip Based Diagnostic Device

• US 20110008225A1
• Filed: 09/21/2010
• Published: 01/13/2011
• Est. Priority Date: 07/02/2004
• Status: Abandoned Application

• Current Assignee: Roche Molecular Systems (Roche Holding AG)
• Original Assignee: Roche Molecular Systems (Roche Holding AG)
• Inventors: Belz, Renato, Carsten, Haack
• Application Number:
  US12/887,337
• Publication Number:
  US 20110008225A1
• Time in Patent Office: Days
• US Class Current: 422/566
• CPC Class Codes: B01J 2219/00495 Means for heating or cooling the reaction vessels
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/00637 by coating it with another layer
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 9/52 Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
• CPC Class Codes: G01N 2035/00158 Elements containing microarrays, i.e. "biochip"
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

A diagnostic device comprising a sample inlet and a processing chamber having a window portion and a flat carrier having front surface, a back surface and one or more side surfaces, said front surface facing said processing chamber, said front surface having an active surface containing a diagnostic reagent immobilized to said active front surface and an extended front surface, wherein said window portion further contains a rim portion facing said extended front surface sealing said chamber versus said carrier through said extended front surface.

Claims

1. An article of manufacture made from a single material and having a substantially flat structure for locking a flat carrier to an analytical device comprising:

a substantially rectangular frame, and

two or more clips spanning the corners of the rectangle being more flexible than the frame.

2. The article of claim 1 wherein the clip is a brace bridging a corner by connecting two adjacent sides of the rectangle.

3. The article of claim 1, wherein there is a gap between each clip and the corner it spans.

4. The article of claim 1, further comprising positioning means.

5. The article of claim 1, further comprising a window formed by said frame and the clips which is larger than 99% of the surface of the flat carrier.