METHODS AND COMPOSITIONS FOR TREATING THYROID-RELATED MEDICAL CONDITIONS WITH REDUCED FOLATES

• US 20110008464A1
• Filed: 07/09/2010
• Published: 01/13/2011
• Est. Priority Date: 07/10/2009
• Status: Active Grant

• Current Assignee: Linzy O. Scott III
• Original Assignee: Linzy O. Scott III
• Inventors: Scott, Linzy O. III
• Granted Patent: US 8,343,974 B2
• Time in Patent Office: Days
• US Class Current: 424/646
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/205 Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 31/7056 containing five-membered rings with nitrogen as a ring hetero atom
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/26 Iron; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: A61P 5/14 of the thyroid hormones, e.g. T3, T4
• CPC Class Codes: A61P 5/16 for decreasing, blocking or antagonising the activity of the thyroid hormones
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 7/06 Antianaemics

Abstract

The present invention provides methods and compositions for treating thyroid-related medical conditions. Many thyroid-related medical conditions exist that go undiagnosed and untreated. These conditions may be prevented and treated with reduced folates and vitamin B12. Administration of reduced folates and vitamin B12 will prevent or treat cerebrospinal folate deficiency, which is linked to thyroid-related medical conditions. Administration of reduced folates and vitamin B12 will also prevent or treat conditions associated with masked megaloblastic anemia and hypothyroidism, and other conditions brought upon through improper thyroid function. Additionally, it is commonplace to treat many thyroid conditions with anti-thyroid drugs or thyroid stimulating drugs. This practice alone is also responsible for causing, or not beneficially addressing, adverse conditions that can be prevented or treated through the methods and compositions discussed herein.

Claims

1. A method of preventing and treating thyroid-related medical conditions comprising the administration of a folate.

2. The method of claim 1, additionally comprising the administration of vitamin B12.

3. The method of claim 1 wherein the thyroid-related medical condition is brought upon by hypothyroidism or hyperthyroidism.

4. The method of claim 1 where the thyroid-related medical condition is cerebrospinal folate deficiency.

5. The method of claim 1 where the thyroid-related medical condition is masked megaloblastic anemia or a masked macrocytic anemia, or a macrocytic anemia.

6. The method of claim 1 where the thyroid-related medical condition is hepatic dysfunction.

7. The method of claim 1 where the thyroid-related medical condition is hypothyroxinemia or other temporary period of hypothyroidism.

8. The method of claim 1 where the thyroid-related medical condition is presented in an individual that is treated with radioactive iodine, has surgery on or related to the thyroid gland or undergoes any other method or procedure to reduce the size or activity of the thyroid gland.

9. The method of claim 1 where the thyroid-related medical condition is presented in an individual that is treated with or takes an anti-thyroid drug or thyroid stimulating drug, or undergoes any treatment intended to increase or decrease thyroid hormone or thyroid function.

10. The method of claim 1 where the thyroid-related medical condition is presented in an individual that is a fetus or a nursing child of a mother or caregiver who has a thyroid-related medical condition.

11. The method of claim 1 where the folate is a reduced folate.

12. The method of claim 1, additionally comprising the administration of Iron.

13. The method of claim 1, additionally comprising the administration of L-Carnitine.

14. The method of claim 1, additionally comprising Calcium or Vitamin D.

15. A composition comprising either an anti-thyroid drug or a thyroid stimulating drug, and a folate.

16. The composition of claim 15, additionally comprising vitamin B12.

17. The composition of claim 15 where the folate is a reduced folate.

18. The composition of claim 15 where the anti-thyroid drug is selected from the group consisting of propylthiouracil, methimazole, carbimazole and potassium perchlorate.

19. The composition of claim 15 where the thyroid stimulating drug is selected from the group consisting of Levothyroxine, Levothyroxine Sodium, Liothyronine Sodium, Liotrix, Thyroglobulin, Thyroid, Thyroxine, Triiodothyronine, Levoxyl, Synthroid, Levo-T, Unithroid, Levothroid, Levoxine, Levolet, Novothyrox, Triostat, Cytomel and Thyrolar.

20. The method of claim 15, additionally comprising either Iron, or L-Carnitine, or Calcium, or Vitamin D.