Markers Associate with Arteriovascular Events and Methods of Use Thereof
First Claim
1. A method for evaluating the risk of a cardiovascular event for a subject comprising measuring at least three component ARTERIORISKMARKERS for the individual selected from the component ARTERIORISKMARKERS within the groups consisting of Core Markers I, Core Markers II, Traditional Laboratory Risk Factors, Clinical Parameters, Supplemental Markers I, and Supplemental Markers II, provided at least one component ARTERIORISKMARKER is selected from the component ARTERIORISKMARKERS within Core Markers I.
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Accused Products
Abstract
Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.
122 Citations
51 Claims
- 1. A method for evaluating the risk of a cardiovascular event for a subject comprising measuring at least three component ARTERIORISKMARKERS for the individual selected from the component ARTERIORISKMARKERS within the groups consisting of Core Markers I, Core Markers II, Traditional Laboratory Risk Factors, Clinical Parameters, Supplemental Markers I, and Supplemental Markers II, provided at least one component ARTERIORISKMARKER is selected from the component ARTERIORISKMARKERS within Core Markers I.
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3. (canceled)
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8-16. -16. (canceled)
- 17. A method for evaluating the risk of a cardiovascular event for a subject comprising measurement of POMC for the individual.
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20-25. -25. (canceled)
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26. A kit comprising at least one reagent for the detection or quantification of POMC.
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27-39. -39. (canceled)
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40. A kit that comprises
a. Reagents for measuring 3 or more component ARTERIORISKMARKERS in a sample from the subject selected from the component ARTERIORISKMARKERS within the group consisting of Core Markers I, Core Markers II, Traditional Laboratory Risk Factors, Supplemental Markers I, and Supplemental Markers II, wherein at least two component ARTERIORISKMARKERS are selected from the component ARTERIORISKMARKERS within Core Markers I and Core Markers II; - and
b. Instructions for use in calculating the index value that evaluates the risk of a cardiovascular event in a subject. - View Dependent Claims (41, 42)
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45-47. -47. (canceled)
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51-59. -59. (canceled)
Specification