LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT
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Abstract
[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides.
[Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I):
[wherein W represents a hydrogen atom, a C1-6 alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C1-6 alkyl, etc.; A1, A2, A3 and A4 each independently represent CH or N].
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Citations
30 Claims
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1-11. -11. (canceled)
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12. A long-chain fatty acyl elongase (LCE) inhibitor comprising, as the active ingredient thereof, a compound of a formula (I) or a pharmaceutically-acceptable salt thereof:
- 23. A compound of Formula I-1 or pharmaceutically salt thereof,
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30. A compound or pharmaceutically acceptable salt thereof, selected from the group consisting of:
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N-(4-methoxyphenyl)-3-(piperidin-1-ylsulfonyl)benzamide; 3-(2-Azabicyclo[2.2.1]hept-2-ylsulfonyl)-N-(3-methoxypyridin-2-yl)benzamide; 3-Isopropoxy-5-{[3-(piperidin-1-ylsulfonyl)benzoyl]amino}-1-1H-pyrazole hydrochloride; N-(3-ethoxypyridin-2-yl)-3-(pyrrolidin-1-ylsulfonyl)benzamide; N-(3-isopropoxy-1H-pyrazol-5-yl)-3-(pyridin-2-ylsulfonyl)benzamide; N-(3-butoxy-1H-pyrazol-5-yl)-3-(pyridin-2-ylsulfonyl)benzamide; N-(4-isopropylphenyl)-3-(phenylsulfonyl)benzamide; N-(5-isopropoxypyridin-2-yl)-3-(pyrimidin-2-ylsulfonyl)benzamide; and [2-{[(4-Isopropoxyphenyl)amino]carbonyl}-4-(piperidin-1-ylsulfonyl)phenoxy]acetic acid.
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Specification