Medical Devices Having Nanostructured Regions For Controlled Tissue Biocompatibility And Drug Delivery
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Accused Products
Abstract
According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.
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Citations
142 Claims
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1-76. -76. (canceled)
- 77. An implantable or insertable medical device comprising (a) a ceramic nanoporous region that comprises interconnected nanopores and (b) a biologically active agent disposed within said interconnected nanopores of said nanoporous region, wherein said biologically active agent is a cell-adhesion promoting biomolecule.
- 81. An implantable or insertable medical device comprising (a) a ceramic nanoporous region that comprises interconnected nanopores and (b) a biologically active agent disposed within said interconnected nanopores of said nanoporous region, wherein said biologically active agent is established within said nanoporous region concurrently with the formation of said nanoporous region and at temperatures below the degradation temperature of the biologically active agent and wherein said biologically active agent is a cell-adhesion promoting biomolecule.
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87. An implantable or insertable medical device comprising a ceramic nanoporous region, said nanoporous region being formed by a method that comprises:
- (a) providing a precursor region comprising a first material that is present in nano-domains within said precursor region;
(b) subjecting said precursor region to conditions under which said first material is either reduced in volume or eliminated from said precursor region, thereby forming a ceramic nanoporous region having interconnected nanopores and (c) introducing a biologically active agent into the interconnected nanopores within said nanoporous region, wherein said biologically active agent is a cell-adhesion promoting-biomolecule. - View Dependent Claims (88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 129, 130, 137, 138)
- (a) providing a precursor region comprising a first material that is present in nano-domains within said precursor region;
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104. An implantable or insertable medical device comprising a ceramic nanostructured region, said nanostructured region provided by a method that comprises one or more of the following processes:
- (a) a physical vapor deposition process comprising evaporation of a metal oxide, (b) a physical vapor deposition process comprising sublimation of a metal or ceramic material, (c) a physical vapor deposition process comprising sputtering of a metal or metal oxide, (d) a physical vapor deposition process comprising laser ablation of a metal or ceramic material, (e) simultaneous physical vapor deposition of (i) a metal or a ceramic material and (ii) a biologically active agent, (f) ion deposition of a metal or metal oxide layer, (h) ion implantation into a metal or ceramic surface, (i) X-ray lithography of a metal or ceramic surface, (j) a kinetic metallization process, (k) chemical vapor deposition of a metal or ceramic material, (l) electrodeposition and (m) electroless deposition, wherein said nanostructured region comprises interconnected nanopores and a biologically active agent disposed within the interconnected nanopores of the nanostructured region and wherein said biologically active agent is a cell-adhesion promoting biomolecule.
- View Dependent Claims (105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 124, 131, 132, 139, 140)
- 122. An implantable or insertable medical device comprising a nanotextured surface region comprising interconnected nanopores and a cell-adhesion-promoting biomolecule provided within the interconnected nanopores of said nanotextured surface region.
Specification