SEQUESTERING SUBUNIT AND RELATED COMPOSITIONS AND METHODS
3 Assignments
0 Petitions
Accused Products
Abstract
A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.
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Citations
48 Claims
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1-38. -38. (canceled)
- 39. A method of treating pain in a human being comprising administering to the human being a plurality of composite subunits, each composite subunit comprising a sequestering subunit comprising naltrexone and a blocking agent comprising a surfactant wherein the blocking agent substantially prevents release of the naltrexone from the sequestering subunit in the gastrointestinal tract, the sequestering subunit being overcoated with an opioid agonist in releasable form.
- 40. The method of 39 wherein the opioid agonist is selected from the group consisting of morphine, hydromorphone, oxycodone, and hydrocodone.
Specification