Discontinuous Surface Coating for Particles

• US 20110014298A1
• Filed: 09/02/2010
• Published: 01/20/2011
• Est. Priority Date: 01/10/2005
• Status: Abandoned Application

• Current Assignee: Aya Shidara, Clara G. Mercado, Eric John Leaver, Francis Martin Friel, Wilson An-Tuen Lee
• Original Assignee: Aya Shidara, Clara G. Mercado, Eric John Leaver, Francis Martin Friel, Wilson An-Tuen Lee
• Inventors: SHIDARA, AYA, LEE, WILSON AN-TUEN, MERCADO, CLARA G., LEAVER, ERIC JOHN, FRIEL, FRANCIS MARTIN
• Application Number:
  US12/874,837
• Publication Number:
  US 20110014298A1
• Time in Patent Office: Days
• US Class Current: 424/497
• CPC Class Codes: A61K 2800/614 By macromolecular compounds
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/29 Titanium; Compounds thereof
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/41 Amines
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/9717 Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
• CPC Class Codes: A61K 8/9728 Fungi, e.g. yeasts
• CPC Class Codes: A61K 8/9771 Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: B01J 13/02 Making microcapsules or microballoons for medical preparations A61K9/50
• CPC Class Codes: C09C 1/3661 Coating
• CPC Class Codes: C09C 1/3676 Treatment with macro-molecular organic compounds
• CPC Class Codes: C09C 1/3684 : Treatment with organo-silicon compounds
• CPC Class Codes: C09C 1/3692 : Combinations of treatments provided for in groups C09C1/3615 - C09C1/3684
• CPC Class Codes: C09C 3/006 : Combinations of treatments provided for in groups C09C3/04 - C09C3/12
• CPC Class Codes: C09C 3/063 : Coating
• CPC Class Codes: C09C 3/10 : Treatment with macromolecular organic compounds C09C3/006 takes precedence
• CPC Class Codes: C09C 3/12 : Treatment with organosilicon compounds C09C3/006 takes precedence

Abstract

The present invention relates to particle compositions comprising a core particle that is partially coated with a first hydrophilic deposit and a hydrophobic polymeric finish, contains a small amount of water, and a compatible active present in the deposit, the finish or both. Additional alternating deposits, hydrophobic, hydrophilic or both, can be present between the first hydrophilic deposit and the hydrophobic polymeric finish. Similarly, additional compatible actives can be present in one or more of the additional alternating deposits. The invention also relates to methods of preparing the particle compositions.

Claims

1. A method for preparing an immediate and time release particle having a surface partially coated comprising the steps of (a) preparing a first hydrophilic deposit and a hydrophobic polymeric finish;

(b) adding a compatible active to the first hydrophilic deposit, the hydrophobic polymeric finish, or both of the deposit and the finish;

(c) partially coating the surface with the first hydrophilic deposit;

(d) drying the particles until between about 0.01 to 25.00 percent by weight of the particle of water remains; and

(e) partially coating the surface with the hydrophobic polymeric finish.

2. The method of claim 1 further comprising the step of partially coating the surface with a first hydrophobic deposit between the step of drying the particles and the step of partially coating the surface with the hydrophobic polymeric finish.

3. The method of claim 2 further comprising the step of partially coating the surface with additional alternating deposits selected from the group consisting of a hydrophilic deposit, a hydrophobic deposit, and a combination thereof, between the step of partially coating the surface with the first hydrophobic deposit and the step of partially coating the surface with the hydrophobic polymeric finish.

4. The method of claim 1 in which the hydrophobic polymeric finish is trimethylsiloxysilicate.

5. The method of claim 2 in which the first hydrophobic deposit is dimethicone.

6. The method of claim 1 in which the first hydrophilic deposit is selected from the group consisting of water, glycols, glycerin, water-based gums, carbomer/water-based gels, acrylates copolymers, quaternary amine compounds, and carbohydrates.

7. The method of claim 1 in which the particle is selected from the group consisting of titanium dioxide, oxides (iron and zinc), mica, silica, bismuth oxichloride, PMMA (polymethylmethacrylate), lakes (aluminum and calcium), talc, plastic powders (BPD 500), salts, sugars, organic pigments, inorganic pigments, organic powders, and inorganic powders.

8. The method of claim 1 further comprising the step of adding the controlled release particles to a cosmetically acceptable carrier.

9. The method of claim 8 further comprising the step of topically applying the particle to the skin containing stratum corneum proteases.

10. The method of releasing actives from partially coated particles to the surface of the skin containing stratum corneum proteases comprising the step of topically applying to the skin, particles prepared according to the method of claim 1.

11. The method of releasing actives from partially coated particles to the surface of the skin containing stratum corneum proteases comprising the step of topically applying to the skin, particles prepared according to the method of claim 3.

12. The method of releasing actives from partially coated particles to the surface of the skin containing stratum corneum proteases comprising the step of topically applying to the skin, particles prepared according to the method of claim 4.