ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
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Accused Products
Abstract
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
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Citations
37 Claims
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1-14. -14. (canceled)
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15. An isolated antisense oligonucleotide of 10 to 50 nucleotides in length selected from
(a) an oligonucleotide that is specifically hybridizable to an exon 53 target region of the Dystrophin gene designated as annealing site H53A (+23+47), annealing site H53A (+39+69), or both; -
(b) an oligonucleotide that is specifically hybridizable to an exon 44 target region of the Dystrophin gene designated as annealing site H44A (+85+104) or annealing site H44A (−
6+14);(c) an oligonucleotide that is specifically hybridizable to an exon 45 target region of the Dystrophin gene designated as annealing site H45A (−
6+20) or annealing site H45A (+71+90); and(d) an oligonucleotide that is specifically hybridizable to an exon 50 target region of the Dystrophin gene designated as annealing site H50A (+02+30) or annealing site H50D (+07−
18). - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification