METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR
First Claim
1. A method for calibrating an optical coherence tomography (OCT) sensor by correlating OCT measurements with blood analyte measurements, comprising:
- receiving blood analyte measurements from a subject over a period of time;
obtaining OCT measurements from biological tissue of the subject using an OCT sensor such that at least one OCT measurement is associated with each blood analyte measurement, each of the OCT measurements capable of being represented as a plot of intensity against depth of the biological tissue;
selecting at least one portion of each of the OCT measurements that includes a selected depth, the selected portion of the OCT measurements correlating with the associated blood analyte measurements; and
determining, using a processor, a calibration relationship for the OCT sensor using the selected portions of the OCT measurements and the associated blood analyte measurements.
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Abstract
The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.
115 Citations
25 Claims
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1. A method for calibrating an optical coherence tomography (OCT) sensor by correlating OCT measurements with blood analyte measurements, comprising:
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receiving blood analyte measurements from a subject over a period of time; obtaining OCT measurements from biological tissue of the subject using an OCT sensor such that at least one OCT measurement is associated with each blood analyte measurement, each of the OCT measurements capable of being represented as a plot of intensity against depth of the biological tissue; selecting at least one portion of each of the OCT measurements that includes a selected depth, the selected portion of the OCT measurements correlating with the associated blood analyte measurements; and determining, using a processor, a calibration relationship for the OCT sensor using the selected portions of the OCT measurements and the associated blood analyte measurements. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A physiological monitoring system for determining a blood analyte level using an optical coherence tomography (OCT) sensor comprising:
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a non-invasive OCT sensor configured to; scan an area of biological tissue and interferometrically scan in a depth dimension during a period of time; and generate one or more OCT measurements based on the scanning; and a physiological monitor comprising at least one processor, the physiological monitor configured to; receive the one or more OCT measurements; select one or more portions of the one or more OCT measurements corresponding to a predetermined depth; and determine an estimated blood analyte level in the biological tissue based on a comparison of the one or more selected portions of the OCT measurements corresponding to the predetermined depth to one or more OCT calibration curves. - View Dependent Claims (23, 24, 25)
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Specification