MEDICAL DEVICE HAVING HYDROPHILIC COATINGS
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Abstract
The present invention relates to a medical device having a coating comprising at least one polyurethane urea, wherein the coating comprises at least one polyurethane urea terminated with a copolymer unit of polyethyloxide and polypropyloxide.
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Citations
27 Claims
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1-10. -10. (canceled)
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11. A medical device having at least one coating comprising at least one polyurethaneurea wherein the polyurethaneurea is terminated with a copolymer unit comprising polyethylene oxide and polypropylene oxide.
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12. The medical device according to claim 11, wherein the polyurethaneurea comprises units which originate from at least one hydroxyl-containing polycarbonate.
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13. The medical device according to claim 11, wherein the polyurethaneurea comprises units which originate from at least one aliphatic, cycloaliphatic or aromatic isocyanate.
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14. The medical device according to claim 11, wherein the polyurethaneurea comprises units which originate from at least one diamine or amine alcohol.
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15. The medical device according to claim 11, wherein the polyurethaneurea is synthesised from components comprising
a) at least one polycarbonate polyol having an average molar weight between 400 g/mol and 6000 g/mol and a hydroxyl functionality of 1.7 to 2.3, or mixtures of such polycarbonate polyols; -
b) at least one aliphatic, cycloaliphatic or aromatic polyisocyanate or mixtures of such polyisocyanates in an amount per mole of the polycarbonate polyol of 1.0 to 4.0 mol; c) at least one monofunctional mixed polyoxyalkylene ether comprising polyethylene oxide and polypropylene oxide or a mixture of such polyethers, having an average molar weight between 500 g/mol and 5000 g/mol, in an amount per mole of the polycarbonate polyol of 0.01 to 0.5 mol; d) at least one aliphatic or cycloaliphatic diamine or at least one amino alcohol, as so-called chain extenders, or mixtures of such compounds in an amount per mole of the polycarbonate polyol of 0.05 to 3.0 mol; e) optionally, one or more short-chain aliphatic polyols having a molar weight between 62 g/mol and 500 g/mol, in an amount per mole of the polycarbonate polyol of 0.1 to 1.0 mol; and f) optionally, amine- or OH-containing units which are located on, and cap, the polymer chain ends.
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16. A process for coating a medical device comprising coating the medical device with at least one polyurethaneurea wherein the polyurethaneurea is terminated with a copolymer unit comprising polyethylene oxide and polypropylene oxide.
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17. The process according to claim 16, wherein the coating is applied to the medical device by knifecoating, printing, transfer coating, spraying, spin coating or dipping.
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18. A medical device obtained according to the process of claim 16.
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19. The medical device according to claim 18, wherein the medical device is a contact lens;
- a cannula;
a catheter;
an embolism filter;
a vena caval filter;
endoscope;
laryngoscope;
tracheal device;
a guide rod;
an insertion guide;
a vascular plug;
a pacemaker component;
a drainage tube;
a guide wire;
a glove;
a stent;
a membrane;
a blood filter;
a device for circulatory support;
a dressing material for wound management;
a urine bag;
a stoma bag;
or a feeding tube.
- a cannula;
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20. The medical device according to claim 19, wherein the medical device is an implant comprising a medically active agent, an implant an extracorporeal blood line, a cochlear implant, or a dental implant tube for feeding.
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21. The medical device according to claim 19, wherein the medical device is a urological catheter;
- a central venous catheter;
an inlet catheter;
an outlet catheter;
a catheter for angioplasty;
a catheter for biopsy;
a catheter used for introducing a stent;
a bronchoalveolar lavage catheter;
a balloon catheter;
or a catheter used in coronary angioplasty.
- a central venous catheter;
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22. The medical device according to claim 20, wherein the medical device is a urinary catheter or a ureteral catheter.
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23. The medical device according to claim 19, wherein the medical device is a dilation balloon.
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24. The medical device according to claim 19, wherein the medical device is an endotracheal tube, a respirator or a tracheal aspiration device.
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25. The medical device according to claim 19, wherein the medical device is a membrane for dialysis.
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26. The medical device according to claim 19, wherein the medical device comprises a medically active agent for a stent, for a balloon surface, or for a contraceptive.
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27. A medical device according to claim 19 in the form of a radioactive stent, a drug-coated stent, bioabsorbable stent or a healing stent.
Specification