GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION
First Claim
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1. A genetically modified animal comprising at least one edited chromosomal sequence encoding an inflammation-related protein.
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Abstract
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins.
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Citations
43 Claims
- 1. A genetically modified animal comprising at least one edited chromosomal sequence encoding an inflammation-related protein.
- 15. A non-human embryo, the embryo comprising at least one RNA molecule encoding a zinc finger nuclease that recognizes a chromosomal sequence encoding an inflammation-related protein, and, optionally, at least one donor polynucleotide comprising a sequence encoding an inflammation-related protein.
- 19. A genetically modified cell, the cell comprising at least one edited chromosomal sequence encoding an inflammation-related protein.
- 31. A method for assessing the effect of a genetically modified inflammation-related protein on the progression or symptoms of an inflammation-related disease state in an animal, the method comprising comparing a wild type animal to a genetically modified animal comprising at least one edited chromosomal sequence encoding an inflammation-related protein, and measuring a phenotype associated with the disease state.
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38. A method for assessing the effect of an agent on progression or symptoms of inflammation, the method comprising:
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a) contacting a genetically modified animal comprising at least one edited chromosomal sequence encoding an inflammation-related protein with the agent; b) measuring an inflammation-related phenotype, and c) comparing results of the inflammation-related phenotype in (b) to results obtained from a control genetically modified animal comprising said edited chromosomal sequence encoding an inflammation-related protein not contacted with the agent. - View Dependent Claims (39, 40, 41, 42, 43)
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Specification