COMBINATIONS TO IMPROVE ANIMAL HEALTH AND PERFORMANCE

• US 20110021461A1
• Filed: 12/30/2008
• Published: 01/27/2011
• Est. Priority Date: 01/04/2008
• Status: Active Grant

• Current Assignee: Novus Carotenoid Technologies SA (Nippon Soda Company Limited)
• Original Assignee: Novus International, Inc. (Nippon Soda Company Limited)
• Inventors: Webb, Steven Andrew, Bowman, Gavin, Manangi, Megharaja K., Harrell, Robert, Zhao, Junmei, Richards, James, Vazquez-Anon, Mercedes
• Granted Patent: US 8,404,714 B2
• Time in Patent Office: Days
• US Class Current: 514/64
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the combinations of the invention comprise antioxidants, trace minerals, organic acids, essential amino acids, and mixtures thereof.

Claims

1-28. -28. (canceled)

29. A method for increasing milk yield and milk efficiency in an animal, the method comprising feeding to the animal as a part of its feed ration a combination comprising at least one antioxidant chosen from 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, tertiary butyl hydroquinone, butylated hydroxyanisole, and butylated hydroxytoluene;

a hydroxy analog of methionine; and

at least one organic trace mineral, the organic trace mineral comprising a metal chelate or a metal salt, the metal chelate or metal salt comprising at least one metal ion and at least one ligand, the ligand comprising a compound comprising Formula (III);

30. The method of claim 29, further comprising the step of determining the milk yield or milk efficiency of the animal.

31. The method of claim 29, wherein the hydroxy analog of methionine is chosen from 2-hydroxy-4-methylthiobutanoic acid and a calcium salt of 2-hydroxy-4-methylthiobutanoic acid.

32. The method of claim 29, wherein the metal ion is chosen from manganese ions, zinc ions, magnesium ions, copper ions, selenium ions, iron ions, and combinations thereof;

and the ligand is 2-hydroxy-4-methylthiobutanoic acid.

33. The method of claim 29, wherein the antioxidant is a mixture of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline and tertiary butyl hydroquinone.

34. The method of claim 29, wherein the hydroxy analog of methionine is a calcium salt of 2-hydroxy-4-methylthiobutanoic acid;

the antioxidant is a mixture of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline and tertiary butyl hydroquinone and the metal ion is a mixture of zinc ions, manganese ions, and copper ions; and

the ligand is 2-hydroxy-4-methylthiobutanoic acid.

35. The method of claim 34, wherein the animal is a dairy cow.

36. The method of claim 35, further comprising the step of determining the milk yield or milk efficiency of the animal.

37. The method of claim 29, further comprising adding at least one organic acid to the combination chosen from formic acid, acetic acid, propionic acid, butanoic acid, benzoic acid, lactic acid, malic acid, tartaric acid, mandelic acid, citric acid, fumaric acid, sorbic acid, boric acid, succinic acid, adipic acid, glycolic acid, glutaric acid, 2-hydroxy-4-methylthiobutanoic acid, and mixtures thereof.

48. The method of claim 29, further comprising the step of increasing the amount of milk fat and milk protein in milk produced by the animal compared to the amount of milk fat and milk protein in milk from the animal feeding the animal a feed ration not containing the combination.

38. A method for increasing the amount of milk fat and milk protein in milk produced by an animal, the method comprising feeding to the animal as a part of its feed ration a combination comprising at least one antioxidant chosen from 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, tertiary butyl hydroquinone, butylated hydroxyanisole, and butylated hydroxytoluene;

a hydroxy analog of methionine; and

at least one organic trace mineral, the organic trace mineral comprising a metal chelate or a metal salt, the metal chelate or metal salt comprising at least one metal ion and at least one ligand, the ligand comprising a compound comprising Formula (III);

39. The method of claim 38, further comprising the step of determining the amount of milk fat and milk protein.

40. The method of claim 38, wherein the hydroxy analog of methionine is chosen from 2-hydroxy-4-methylthiobutanoic acid and a calcium salt of 2-hydroxy-4-methylthiobutanoic acid.

41. The method of claim 38, wherein the metal ion is chosen from manganese ions, zinc ions, magnesium ions, copper ions, selenium ions, iron ions, and combinations thereof;

and the ligand is 2-hydroxy-4-methylthiobutanoic acid.

42. The method of claim 38, wherein the antioxidant is a mixture of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline and tertiary butyl hydroquinone.

43. The method of claim 38, wherein the hydroxy analog of methionine is a calcium salt of 2-hydroxy-4-methylthiobutanoic acid;

the antioxidant is a mixture of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline and tertiary butyl hydroquinone and the metal ion is a mixture of zinc ions, manganese ions, and copper ions; and

the ligand is 2-hydroxy-4-methylthiobutanoic acid.

44. The method of claim 43, wherein the animal is a dairy cow.

45. The method of claim 44, further comprising the step of determining the amount of milk fat and milk protein.

46. The method of claim 38, further comprising adding at least one organic acid to the combination chosen from formic acid, acetic acid, propionic acid, butanoic acid, benzoic acid, lactic acid, malic acid, tartaric acid, mandelic acid, citric acid, fumaric acid, sorbic acid, boric acid, succinic acid, adipic acid, glycolic acid, glutaric acid, 2-hydroxy-4-methylthiobutanoic acid, and mixtures thereof.

47. The method of claim 38, further comprising the step of increasing milk yield and milk efficiency without an increase in the animal'"'"'s dry matter intake compared to feeding the animal a feed ration not containing the combination.

49. A method for increasing milk yield and milk efficiency in an animal and for increasing the amount of milk fat and milk protein in milk produced from the animal, the method comprising feeding to the animal as a part of its feed ration a combination comprising a calcium salt of 2-hydroxy-4-methylthiobutanoic acid;

6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline;

tertiary butyl hydroquinone;

a metal chelate comprising zinc ions and a ligand comprising 2-hydroxy-4-methylthiobutanoic acid;

a metal chelate comprising manganese ions and a ligand comprising 2-hydroxy-4-methylthiobutanoic acid; and

a metal chelate comprising copper ions and a ligand 2-hydroxy-4-methylthiobutanoic acid;

wherein the amount of milk fat and milk protein in milk produced by the animal is increased compared to the amount of milk fat and milk protein in milk from the animal feeding the animal a feed ration not containing the combination and increasing milk yield and milk efficiency without an increase in the animal'"'"'s dry matter intake compared to feeding the animal a feed ration not containing the combination.

50. The method of claim 49, further comprising the step of determining the milk yield or milk efficiency of the animal.

51. The method of claim 49, further comprising the step of determining the amount of milk fat and milk protein.

52. The method of claim 49, wherein the animal is a dairy cow.