Subcutaneous Glucose Electrode
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Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer can be overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited. An outer layer is preferably biocompatible.
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Citations
53 Claims
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1-20. -20. (canceled)
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21. A glucose sensor comprising:
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a working electrode; and a multilayer membrane complex comprising; an analyte responsive sensing layer disposed on top and in electrical contact with the working electrode, the analyte responsive sensing layer comprising a glucose-specific enzyme, a mediator and a first polymer selected from the group consisting of poly(vinylimidazole), poly(vinylpyridine) and poly(acrylamide co-I-vinylimidazole), wherein at least one of the glucose-specific enzyme and the mediator is chemically bonded to the first polymer; and a diffusion-limiting layer comprising a second polymer disposed on top and in contact with the analyte responsive sensing layer. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification