Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens

• US 20110021896A1
• Filed: 09/30/2010
• Published: 01/27/2011
• Est. Priority Date: 05/15/2001
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Cho, Hyun, Mao, Fei
• Application Number:
  US12/895,633
• Publication Number:
  US 20110021896A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.

Claims

1. (canceled)

2. A sensor for continuous measurement of an analyte concentration, the sensor comprising:

an electrode and a membrane located over the electrode, the membrane comprising;

a first domain comprising a polymer having a surface active group, the first domain configured to control a flux of an analyte therethrough and to substantially reduce or block a flux of an endogenous interferent therethrough; and

a second domain comprising an enzyme.

3. The sensor of claim 2, wherein the first domain is configured to substantially reduce or block a flux of an exogenous interferent therethrough.

4. The sensor of claim 2, wherein the polymer comprises a blend of a base polymer and a hydrophilic polymer.

5. The sensor of claim 4, wherein the hydrophilic polymer is a polymer selected from the group consisting of polyvinyl acetate, poly(ethylene glycol), polyacrylamide, acetates, polyethylene oxide, poly ethyl acrylate, and polyvinylpyrrolidone.

6. A device for continuous measurement of an analyte concentration, the device comprising:

a sensing mechanism configured to generate a signal associated with a concentration of an analyte in a host; and

a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a polymer comprising a surface-active group incorporated therein.

7. The device of claim 6, wherein the surface-active group is covalently bonded to the polymer.

8. The device of claim 6, wherein the surface-active group comprises a surface-active end group.

9. The device of claim 6, wherein the polymer is a polymer selected from the group consisting of polyvinyl acetate, poly(ethylene glycol), polyacrylamide, acetates, polyethylene oxide, poly ethyl acrylate, and polyvinylpyrrolidone.

10. The device of claim 6, wherein the analyte is glucose.

11. The device of claim 6, wherein the sensing mechanism comprises an electrode.

12. The device of claim 6, wherein the bioprotective domain is configured to control a flux of the analyte therethrough.

13. The device of claim 6, wherein the sensing membrane further comprises a resistance domain configured to control a flux of the analyte therethrough.

14. The device of claim 6, wherein the sensing membrane further comprises an enzyme domain comprising a catalyst.

15. The device of claim 14, wherein the catalyst is incorporated into the bioprotective domain.

16. The device of claim 6, wherein the polymer comprises at least one polymer selected from the group consisting of epoxies, polyolefins, polysiloxanes, polyethers, acrylics, polyesters, carbonates, and polyurethanes.

17. The device of claim 6, wherein the surface-active group comprises silicone.

18. The device of claim 6, wherein the bioprotective domain is configured to control a flux of an analyte therethrough and to substantially reduce or block a flux of an endogenous interferent therethrough.

19. A device for continuous measurement of glucose concentration, the device comprising:

a sensing mechanism configured to generate a signal associated with a concentration of glucose in a host; and

a sensing membrane located over the sensing mechanism, the sensing membrane comprising a bioprotective domain comprising a surface-active end group covalently bonded to a base polymer.

20. The device of claim 19, wherein the bioprotective domain is configured to control a flux of glucose therethrough and to substantially reduce or block a flux of an endogenous interferent therethrough.