STRUCTURE OF MICRO-NEEDLE WITH SIDE CHANNEL AND MANUFACTURING METHOD THEREOF

• US 20110021996A1
• Filed: 09/30/2010
• Published: 01/27/2011
• Est. Priority Date: 12/18/2008
• Status: Abandoned Application

• Current Assignee: Miti Systems, Inc.
• Original Assignee: Miti Systems, Inc.
• Inventors: Han, Man Hee, Sul, Boo Joon, Lee, Seung Seob
• Application Number:
  US12/895,378
• Publication Number:
  US 20110021996A1
• Time in Patent Office: Days
• US Class Current: 604/173
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: C25D 1/02 Tubes; Rings; Hollow bodies

Abstract

The present invention relates to a microneedle for delivering active agent or agents. The microneedle comprises a body a body having a base at one end thereof and a tip portion at the other end thereof; a pair of projections connected to a side of the body and having a base at one end thereof and a tip portion at the other end thereof; and a vertical groove defined by the body and the pair of projections. The distance between outer edges of the pair of projections is formed to become smaller towards the tip portion than the distance between outer edges of the body, and the upper end of each of the pair of projections is shorter than that of the body such that a free space is formed between the outer edges of the body and the pair of projections.

Claims

1. A microneedle for delivering active agent or agents, the microneedle comprising:

a body having a base at one end thereof and a tip portion at the other end thereof;

a pair of projections connected to a side of the body and having a base at one end thereof and a tip portion at the other end thereof; and

a vertical groove defined by the body and the pair of projections;

wherein the distance between outer edges of the pair of projections is formed to become smaller towards the tip portion than the distance between outer edges of the body, and the upper end of each of the pair of projections is shorter than that of the body such that a free space is formed between the outer edges of the body and the pair of projections.

2. The microneedle according to claim 1, wherein the body and the pair of projections are formed integrally.

3. The microneedle according to claim 1, wherein the body, the base thereof, and the tip portion thereof are formed integrally.

4. The microneedle according to claim 1, wherein the pair of projections, the base thereof, and the tip portion thereof are formed integrally.

5. A method for manufacturing the microneedle according to claim 1, comprising the steps of:

(a) forming on a light-transmitting substrate a light-shielding pattern having the shape of a planar cross-section of the microneedle;

(b) coating the light-transmitting substrate with a photoresist, masking the photoresist in a light-shielding pattern corresponding to the vertical groove, and exposing the masked photoresist to light to thereby define projections for the vertical groove;

(c) coating the light-transmitting substrate with a photoresist, exposing and developing the photoresist from the bottom surface of the light-transmitting substrate to thereby form a mold for the microneedle formed with the vertical groove;

(d) depositing an electroplating seed layer on the top surface of the mold to form a plating layer; and

(e) removing the plating layer by performing a plating process on the electroplating seed layer.

6. The method according to claim 5, wherein the light-shielding pattern corresponding to the vertical groove in the step (b) is configured in such a fashion that a slit corresponding to the vertical groove is formed in a tip of the microneedle, and the width and length thereof are smaller by a predetermined dimension than those of the light-shielding pattern having the planar cross-section shape of the microneedle in the step (a).

7. The method according to claim 6, wherein the light-shielding pattern having the planar cross-section shape of the microneedle and the light-shielding pattern corresponding to the vertical groove become narrower as they go toward the top.

8. The method according to claim 5, wherein in the step (a), the light-shielding pattern has the shape of a planar cross-section of a tip of the microneedle, and the step (c) comprises exposing the photoresist to light from the bottom surface of the light-transmitting substrate, placing a light-shielding pattern having the shape of a planar cross-section of a base of the microneedle on the top surface of the light-transmitting substrate, and exposing and developing the photoresist from the top surface of the light-transmitting substrate.

9. The method according to claim 5, wherein the light-shielding pattern in the step (a) has the shape of the planar cross-section of one or more microneedles which are arranged in parallel with each other.

10. The method according to claim 5, wherein the exposing of the photoresist in the step (c) is performed in an inclined manner.

11. The method according to claim 5, further comprising the steps of:

(f) fabricating a negative mold using the removed plating layer as an original form; and

(e) obtaining a molded product made of a polymer material using the negative mold.

12. An out-of-plane microneedle sheet comprising a plurality of microneedles according to claim 1 applied thereon.

13. The out-of-plane microneedle sheet according to claim 12, wherein the sheet comprises a through-recess formed therein so as to store or transport active agent or agents, the through-recess being adapted to fluidically communicate with the vertical groove of the microneedle.