METHOD AND APPARATUS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION EMPLOYING FLUID JET

• US 20110022010A1
• Filed: 09/21/2010
• Published: 01/27/2011
• Est. Priority Date: 07/18/2005
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Roe, Steven, Grenon, Stephen M., Korb, Donald R., Paul, Lyle
• Granted Patent: US 8,628,504 B2
• Time in Patent Office: Days
• US Class Current: 604/294
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 2018/046 in liquid form
• CPC Class Codes: A61B 2018/048 in gaseous form
• CPC Class Codes: A61F 2007/0004 Eyes or part of the face surrounding the eyes
• CPC Class Codes: A61F 2007/0059 with an open fluid circuit
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0026 Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61H 2015/0014 cylinder-like, i.e. rollers
• CPC Class Codes: A61H 2201/0207 heated
• CPC Class Codes: A61H 2201/0221 Mechanism for heating or cooling
• CPC Class Codes: A61H 2201/1607 Holding means therefor
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2205/022 Face
• CPC Class Codes: A61H 2205/024 Eyes
• CPC Class Codes: A61H 35/02 for the eyes
• CPC Class Codes: A61H 7/00 Devices for suction-kneading massage; Devices for massaging the skin by rubbing or brushing not otherwise provided for electro-medical massage devices applying electric current by contact A61N1/18
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

Claims

1. An apparatus for treating meibomian gland dysfunction in an eyelid wherein at least one occlusion blocks at least a portion of a flow of naturally occurring secretion out of at least one meibomian gland, comprising:

a mask configured to deliver and maintain at a pressure from about 2 psi to about 30 psi the application of at least one jet of heated medium to an exterior surface of a closed eyelid, proximate to at least one meibomian gland, for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of at least one occlusion in the at least one meibomian gland such that at least a portion of the at least one occlusion is removed.

2. The apparatus of claim 1, wherein the mask further comprises at least one eyepiece configurable to cover an orbit of an eye and eyelid.

3. The apparatus of claim 2, wherein the at least one eyepiece further comprises an oval annulus or ring.

4. The apparatus of claim 3, wherein the at least one eyepiece is composed of a flexible material.

5. The apparatus of claim 1, wherein the heated medium is configured to maintain the temperature of the meibomian gland from at least 40 degrees Celsius to 47 degrees Celsius.

6. The apparatus of claim 4, wherein the flexible material is comprised from the group consisting of rubber, plastic, and neoprene.

7. The apparatus of claim 2, wherein the at least one eyepiece is configurable to create a seal around the orbit of an eye and eyelid.

8. The apparatus of claim 7, wherein the seal is comprised of a water tight seal.

9. The apparatus of claim 3, further comprising a lens mounted to the oval annulus or ring.

10. The apparatus of claim 3, further comprising a membrane communicating with the oval annulus or ring and configurable to cover and contact an eyelid;

wherein the membrane is further configured to receive the at least one jet of heated medium from the mask and thereby transmitting a force of the at least one jet to the eyelid so as to soften the at least a portion of the at least one occlusion in the at least one meibomian gland.

11. The apparatus of claim 3, further comprising a nose bridge connecting the at least one eyepiece to a second eyepiece.

12. The apparatus of claim 3, further comprising a headband configured to connect outer edges of the mask and further configurable to maintain the mask firmly in place against orbit and cheek areas surrounding an eye.

13. The apparatus of claim 12, wherein the headband is composed of a flexible material.

14. The apparatus of claim 13, wherein the flexible material is comprised from the group consisting of rubber, plastic, and neoprene.

15. The apparatus of claim 1, wherein the heated medium is comprised from the group consisting of fluids, gases, and flowable creams.

16. The apparatus of claim 1, wherein the mask is configurable to be attached to a mammal so as to position the at least one jet of heated medium to the exterior surface of the closed eyelid.

17. The apparatus of claim 1, wherein the mask is configurable to be positioned by manually holding the apparatus so as to position the at least one jet of heated medium to the exterior surface of the closed eyelid.

18. An apparatus for treating meibomian gland dysfunction in an eyelid wherein at least one occlusion blocks at least a portion of a flow of naturally occurring secretion out of at least one meibomian gland, comprising:

at least one jet configured to deliver and maintain at a pressure from about 2 psi to about 30 psi the application of at least one jet of heated medium to an exterior surface of a closed eyelid, proximate to at least one meibomian gland, for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of at least one occlusion in the at least one meibomian gland such that the at least a portion of the at least one occlusion is removed.

19. The apparatus of claim 18, further comprising a rotary distributor valve configured to deliver a heated medium to the at least one jet.

20. The apparatus of claim 19, wherein the rotary distributor valve further comprises a cylindrical manifold having a bore extending along its length.

21. The apparatus of claim 20, wherein the rotary distributor valve further comprises at least one jet orifice positioned along a portion of the cylindrical manifold, wherein the at least one jet orifice is in fluid communication with the bore.

22. The apparatus of claim 21, wherein the rotary distributor valve further comprises a housing surrounding the cylindrical manifold having the bore extending along its length.

23. The apparatus of claim 22, wherein the housing further comprises a longitudinal slit configured to allow fluid from the at least one jet orifice to pass there through such that upon rotation of the cylindrical manifold, the at least one jet orifice is sequentially exposed to the longitudinal slit.

24. The apparatus of claim 22, wherein the cylindrical manifold is mounted for rotation within the housing.

25. The apparatus of claim 21, wherein the rotary distributor valve further comprises an integrally molded gear communicating with the cylindrical manifold and configured to rotate the cylindrical manifold.

26. The apparatus of claim 25, wherein the rotary distributor valve further comprises a rotor communicating with the manifold through the gear and configured to rotate the manifold.

27. The apparatus of claim 21, wherein the rotary distributor valve further comprises:

a first nipple communicating with a first end of the cylindrical manifold in fluid communication with the bore; and

a second nipple communicating with a second end of the cylindrical manifold in fluid communication with the bore.

28. The apparatus of claim 27, wherein the first nipple is configured as a fluid inlet.

29. The apparatus of claim 27, wherein the second nipple is configured as a fluid outlet.

30. The apparatus of claim 27, wherein the cylindrical manifold is mounted for rotation between the first and second nipples.

31. The apparatus of claim 21, wherein the rotary distributor valve further comprises:

a pump in fluid communication with the cylindrical manifold configured to deliver the heated medium into the cylindrical manifold; and

a rotor communicating with the cylindrical manifold and configured to rotate the bore so as to rotate the position of the at least one jet orifice.

32. The apparatus of claim 31, wherein the rotary distributor valve is configured to milkingly massage the at least one meibomian gland so as to soften the at least a portion of the at least one occlusion.

33. The apparatus to claim 31, wherein the rotary distributor valve is configured to apply the at least one jet to the at least one meibomian gland in a manner that milkingly moves up the at least one meibomian gland from an end opposite at least one meibomian gland channel orifice towards the at least one meibomian gland channel orifice.

34. The apparatus of claim 31, wherein the pump maintains a pressure of the heated medium into the cylindrical manifold.

35. The apparatus of claim 31, wherein the rotary distributor valve further comprises a heater configured to maintain a temperature of the heated medium.

36. The apparatus of claim 35, wherein the heater is configured to supply heat to the heated medium by a modality selected from the group consisting of conduction, convection, and radiation.

37. The apparatus of claim 35, wherein the heater is configured to maintain the temperature of at least a portion of the heated medium to at least 42 degrees Celsius.

38. The apparatus of claim 37, wherein the heater is configured to maintain the temperature of the at least a portion of the heated medium to at most 46 degrees Celsius.

39. The apparatus of claim 21, wherein the application of the at least one jet of heated medium is intermittent.

40. The apparatus of claim 39, wherein the intermittent application of the at least one jet of heated medium is pulsed.

41. The apparatus of claim 39, wherein the at least one jet of heated medium is applied at a frequency between 1 Hz and 300 Hz.

42. The apparatus of claim 39, wherein the at least one jet of heated medium is applied at a frequency between 5 Hz and 60 Hz.

43. The apparatus of claim 18, wherein the heated medium is comprised from the group consisting of fluids, gases, and flowable creams.

44. The apparatus of claim 18, wherein the at least one jet is configured to be repositionable during the application of the at least one jet of heated medium.

45. The apparatus of claim 18, wherein the at least one jet is not configured to be repositionable during the application of the at least one jet of heated medium.

46. An apparatus for treating meibomian gland dysfunction in a mammal wherein at least one occlusion blocks at least a portion of a flow of naturally occurring secretion out of at least one meibomian gland, comprising:

at least one jet configured to deliver and maintain at a pressure from about 2 psi to about 30 psi the application of at least one jet of heated medium to maintain the internal temperature of at least one meibomian gland between 40 degrees Celsius and 47 degrees Celsius, for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of at least one occlusion in the at least one meibomian gland such that the at least a portion of the at least one occlusion is removed.