SYSTEMS AND METHODS FOR DETERMINING VENTRICULAR PACING SITES FOR USE WITH MULTI-POLE LEADS

• US 20110022112A1
• Filed: 12/16/2009
• Published: 01/27/2011
• Est. Priority Date: 07/22/2009
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Min, Xiaoyi
• Granted Patent: US 9,387,329 B2
• Time in Patent Office: Days
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Techniques are provided for use by implantable medical devices for controlling multi-site left ventricular (MSLV) pacing using a multi-pole left ventricular (LV) lead. In various examples, a reduced number of “V sense”, “RV pace”, and “LV pace” tests are performed to determine preferred or optimal interventricular pacing delays (VV) for use with MSLV pacing. Additionally, techniques are described for sorting the order by which LV sites are to be paced during MSLV pacing. Furthermore, techniques are described for detecting and addressing circumstances where AV/PV delays are longer than corresponding AR/PR delays during MSLV.

Claims

1. A method for controlling multi-site ventricular pacing for use by an implantable cardiac rhythm management device equipped with a multi-pole ventricular lead having a plurality of electrodes, the method comprising:

determining preliminary multi-site interventricular pacing delays (VVT) for the plurality of electrodes of the multi-pole lead based, at least in part, on multi-site interventricular conduction time delay values (Δ

) determined for the electrodes;

determining multi-site interelectrode pacing delays (IVV) for the plurality of electrodes of the multi-pole lead based the preliminary interventricular pacing delays (VVT);

determining an order by which the electrodes of the multi-pole lead are to be used to deliver a set of multi-site pacing pulses, with the order determined based on the interelectrode pacing time delays (IVV); and

delivering multi-site ventricular pacing by delivering a set of pulses using the electrodes of the multi-pole lead in the determined order.

2. The method of claim 1 wherein the multi-pole lead is a left ventricular (LV) lead having a plurality of electrodes (LV_n) and the device is equipped with a right ventricular (RV) lead and wherein the method is performed to deliver multi-site LV (MSLV) pacing using the plurality of electrodes (LV_n) of the multi-pole LV lead, where n=1, 2 . . . , N.

3. The method of claim 2 wherein determining the preliminary interventricular pacing delays (VVT) includes setting an individual preliminary interventricular pacing delay (VVT_n) for use with a selected electrode (LV_n) of the LV lead based on:

VVT_n=α

*(Δ

′

_n+ε

_n);

wherein α

_n is a coefficient, Δ

′

_n is an intrinsic interelectrode conduction time delay, ε

_n is an interventricular correction term for use with the selected electrode (LV_n) of the LV lead and N represents the total number of electrodes of the multi-pole lead.

4. The method of claim 3 wherein the intrinsic interelectrode conduction time delays (Δ

′

_n) are determined using;

Δ

′

_n=Δ

_n−

Δ

<sub>n−

1</sub>;

where n=2, 3, . . . , N

Δ

′

₁=Δ

₁

wherein Δ

_n is a measured intrinsic interventricular conduction time delay for the nth electrode of the multi-pole lead.

5. The method of claim 4 wherein the interventricular correction term (ε

_n) is determined based on;

ε

_n=IVCD(L_nL<sub>n−

1</sub>)−

IVCD(L<sub>n−

1</sub>L_n) where n=2, 3, . . . , N

ε

₁=IVCD(L₁R)−

IVCD(RL₁)

wherein each value of IVCD represents a paced interventricular conduction time delay (IVCD).

6. The method of claim 3 wherein determining multi-site interelectrode pacing delays (IVV) for the plurality of electrodes based the preliminary interventricular pacing delays (VVT) includes:

sequentially summing values of VVT_n to generate corresponding values for IVV_n.

7. The method of claim 6 wherein determining an order by which the electrodes of the multi-pole lead are to be used to deliver a set of multi-site pacing pulses:

determining absolute values of each of the IVV_n values;

identifying a particular IVV_n value having a maximum absolute value and then selecting the corresponding electrode as being a first electrode to be used for delivering MSLV pacing; and

repeating the process with the remaining IVV_n values and the remaining electrodes to iteratively sort the IVV_n values and the corresponding electrodes.

8. The method of claim 7 wherein delivering multi-site ventricular pacing includes:

determining final interventricular pacing delays (VV_n) for use with each of the electrodes of the LV lead based on differences between IVV_n values of the electrodes;

delivering a first MSLV pulse using the first selected electrode; and

delivering additional MSLV pulses using the other electrodes of the multi-pole lead in the sorted order and subject to the final interventricular pacing delays VV_n.

9. The method of claim 8 further including a predecessor step of determining multi-site interventricular conduction time delay values (Δ

) for the electrodes of the LV lead by;

identifying an electrical event sufficient to trigger ventricular depolarization within the heart of a patient in which the device is implanted;

detecting a resulting ventricular depolarization at each of a plurality of electrodes of the LV lead, the depolarization being detected at generally different times at each different electrode; and

determining multi-site interventricular conduction time delays (Δ

_n) for each of the plurality of electrodes of the LV lead based on the depolarization triggered by the electrical event.

10. The method of claim 9 wherein detecting the resulting ventricular depolarization at each of a plurality of electrodes of the LV lead includes detecting a resulting LV QRS complex (LV_n QRS) at each of the plurality of LV electrodes (LV_n) of the LV lead.

11. The method of claim 1 wherein all of the steps are performed by the implantable medical device.

12. The method of claim 1 wherein at least some of the steps are performed by an external device based on signals received from the implantable medical device.

13. A system for controlling ventricular pacing for use by an implantable cardiac rhythm management device equipped with a multi-pole ventricular lead having a plurality of electrodes, the system comprising:

a multi-site interventricular pacing delay determination unit operative to determine preliminary multi-site interventricular pacing delays (VVT) for the plurality of electrodes of the multi-pole lead based, at least in part, on multi-site interventricular conduction time delay values (Δ

) determined for the electrodes;

a multi-site interelectrode pacing delay determination unit operative to determine multi-site interelectrode pacing delays (IVV) for the plurality of electrodes of the multi-pole lead based the preliminary interventricular pacing delays (VVT);

a multi-pole pacing site ordering unit operative to determine an order by which the electrodes of the multi-pole lead are to be used to deliver a set of multi-site pacing pulses, with the order determined based on the interelectrode pacing time delays (IVV); and

a multi-pole ventricular pacing controller operative to deliver a set of pulses using the electrodes of the multi-pole lead.

14. A system for controlling ventricular pacing for use by an implantable cardiac rhythm management device equipped with a multi-pole ventricular lead having a plurality of electrodes, the system comprising:

means for determining preliminary multi-site interventricular pacing delays (VVT) for the plurality of electrodes of the multi-pole lead based, at least in part, on multi-site interventricular conduction time delay values (Δ

) determined for the electrodes;

means for determining multi-site interelectrode pacing delays (IVV) for the plurality of electrodes of the multi-pole lead based the preliminary interventricular pacing delays (VVT);

means for determining an order by which the electrodes of the multi-pole lead are to be used to deliver a set of multi-site pacing pulses, with the order determined based on the interelectrode pacing time delays (IVV); and

means for delivering multi-site ventricular pacing by delivering a set of pulses using the electrodes of the multi-pole lead.