Device including altered microorganisms, and methods and systems of use
First Claim
Patent Images
1. A device, comprising:
- at least one semi-permeable barrier substantially enclosing at least one auxotrophic microorganism, the at least one auxotrophic microorganism including at least one nucleic acid construct encoding at least one therapeutic agent, the barrier defining an interior region and exterior region; and
wherein the device includes at least one metabolite required by the at least one auxotrophic microorganism.
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Accused Products
Abstract
Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.
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Citations
108 Claims
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1. A device, comprising:
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at least one semi-permeable barrier substantially enclosing at least one auxotrophic microorganism, the at least one auxotrophic microorganism including at least one nucleic acid construct encoding at least one therapeutic agent, the barrier defining an interior region and exterior region; and wherein the device includes at least one metabolite required by the at least one auxotrophic microorganism. - View Dependent Claims (2, 3, 4, 5, 8, 10, 13, 14, 15, 17, 25, 26, 28, 38, 39, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 54, 55, 56, 59, 60, 61, 67, 70, 71, 72, 73, 74, 75, 76, 78, 79, 80, 81, 82, 83, 84, 95, 96, 97, 98, 99, 104, 107)
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Specification