KITS AND METHODS FOR ASSESSING ANTIOXIDANT REQUIREMENT OF A HUMAN
First Claim
1. A method of assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2), the method comprising assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism, whereby occurrence of a copy of the polymorphism is an indication that it is more desirable to supplement the human'"'"'s diet with CoQH2 than that of a human whose genome does not comprise the polymorphism.
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Abstract
The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2). The methods involve assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism of the NQO1 gene. Occurrence of a copy of the polymorphism indicates that the human can benefit from dietary supplementation with CoQH2, and occurrence of two copies (i.e., homozygosity) of the NQO1*2 polymorphism indicates that dietary supplementation with CoQH2 can be especially desirable.
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Citations
20 Claims
- 1. A method of assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2), the method comprising assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism, whereby occurrence of a copy of the polymorphism is an indication that it is more desirable to supplement the human'"'"'s diet with CoQH2 than that of a human whose genome does not comprise the polymorphism.
- 14. A method of formulating a coenzyme Q-(CoQ-)containing antioxidant composition for administration to a human, the method comprising assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism and including CoQH2 in the composition if the polymorphism occurs in the genome.
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16. A method of assessing the advisability that a human should employ a dietary supplement comprising CoQH2, the method comprising assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism, whereby occurrence of a copy of the polymorphism is an indication that the human should employ a dietary supplement comprising CoQH2.
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17. A method of assessing the advisability that a human should employ a dietary supplement comprising CoQH2, the method comprising assessing occurrence in the human'"'"'s genome of the NQO1*2 polymorphism, whereby homozygosity of the human for the polymorphism is an indication that the human should employ a dietary supplement comprising CoQH2.
- 18. A method of assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2), the method comprising assessing occurrence in the human'"'"'s genome of a null NQO1 polymorphism, whereby occurrence of a copy of the null polymorphism is an indication that it is more desirable to supplement the human'"'"'s diet with CoQH2 than that of a human whose genome does not comprise the null polymorphism.
Specification