METHOD AND DEVICE FOR NON-INVASIVE DETERMINATION OF THE CONCENTRATION OF A SUBSTANCE IN A BODY FLUID
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Abstract
The present invention relates generally to the field of measuring glucose levels in a body fluid of a subject, in particular to non-invasive measuring of blood glucose in blood of a subject. A device is disclosed comprising an electrically conducting probe comprising a plurality of electrodes adapted for measuring electrical impedance of the tissue of a subject, typically skin, a sensing device adapted for sensing at least one concentration of an ion in the tissue, typically acidity (pH), wherein said electrically conducting probe and said sensing device are adapted to obtain said electrical impedance of the tissue and said concentration of an ion in the tissue simultaneously. The device further comprises a blood glucose determining unit adapted for determining an estimate, typically a concentration, of blood glucose based on said electrical impedance of the tissue and said concentration of an ion in the tissue. Further, a device is disclosed comprising an electrically conducting probe comprising a plurality of electrodes adapted for measuring electrical impedance of the tissue of a subject, typically the skin, wherein at least one of said plurality of electrodes is adapted to, when being in voltage mode, sense a signal representative of a concentration of an ion in the tissue, typically acidity (pH), wherein said electrically conducting probe is adapted to simultaneously obtain said impedance of the tissue and said concentration of an ion in the tissue, the device also comprising a blood glucose determining unit adapted for determining an estimate, typically a concentration, of blood glucose based on said electrical impedance of the tissue and said concentration of an ion in the tissue. Furthermore, methods for non-invasive determination of an estimate of blood glucose in blood of a subject are disclosed.
45 Citations
56 Claims
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1-44. -44. (canceled)
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45. A device for non-invasive determination of an estimate of glucose in the blood of a subject, comprising:
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an electrically conducting probe comprising a plurality of electrodes adapted to measure the impedance of the tissue of a subject, at least one sensing device adapted to sense at least one concentration acidity (pH) in the tissue of a subject, wherein said electrically conducting probe and said sensing device are adapted to substantially simultaneously measure the impedance of the tissue and sense a concentration of acidity (pH) in the tissue, respectively, and a blood glucose determining unit adapted to determine an estimate of blood glucose of said subject based on said tissue impedance and said acidity (pH) concentration. - View Dependent Claims (49, 50, 51, 52, 53, 54)
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46. A device for non-invasive determination of an estimate of blood glucose in the blood of a subject, comprising:
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an electrically conducting probe comprising a plurality of electrodes adapted to measure a value of the impedance of the tissue of a subject, wherein at least one of said plurality of electrodes is adapted for, when being in voltage mode, sense a signal representing a value of the concentration of acidity (pH) in the tissue of a subject, and wherein said electrically conducting probe is adapted to substantially simultaneously obtain said value of the impedance of the tissue of a subject and said value of the concentration of acidity (pH) in the tissue of a subject, and a blood glucose determining unit adapted to determine an estimate of blood glucose of said subject based on said tissue impedance and said acidity (pH) concentration. - View Dependent Claims (47, 48)
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55. A method for non-invasive determination of an estimate of blood glucose in the blood of a subject, said method comprising the steps of:
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(a) placing an electrically conducting probe against a tissue surface of a subject wherein said probe comprises a plurality of electrodes and at least one sensing device or sensor adapted for sensing a concentration of acidity (pH) in the tissue; (b) passing an electrical current through the electrodes to obtain a value of the impedance of the tissue; (c) using said at least one sensing device or sensor to obtain at least one value of a concentration of acidity (pH) in the tissue, (d) wherein said value of the impedance of the tissue and said at least one value of a concentration of acidity (pH) in the tissue are obtained substantially simultaneously; and (e) determining an estimate of blood glucose in blood of a subject on the basis of said at least one value of a concentration of acidity (pH) and said impedance value.
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56. A method for non-invasive determination of an estimate of blood glucose in blood of a subject, said method comprising the steps of:
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(a) placing an electrically conducting probe against a tissue surface of a subject, wherein said probe comprises a plurality of electrodes, and wherein at least one of said plurality of electrodes is adapted for, when being in voltage mode, sensing a signal representing a value of a concentration of acidity (pH) in the tissue of a subject; (b) passing an electrical current through the electrodes to obtain a value of the impedance of the tissue; (c) using said at least one electrode adapted for sensing a signal representing a value of a concentration of acidity (pH) in the tissue of a subject to obtain at least one value of a concentration of acidity (pH) in the tissue, (d) wherein said value of the impedance of the tissue and said at least one value of a concentration of acidity (pH) in the tissue are obtained substantially simultaneously; and (e) determining an estimate of blood glucose in blood of a subject on the basis of said at least one value of a concentration of acidity (pH) and said impedance value.
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Specification