PATCH

• US 20110028880A1
• Filed: 02/09/2009
• Published: 02/03/2011
• Est. Priority Date: 02/27/2008
• Status: Abandoned Application

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Uchida, Naoyuki, Fujita, Naoko
• Application Number:
  US12/919,739
• Publication Number:
  US 20110028880A1
• Time in Patent Office: Days
• US Class Current: 602/48
• CPC Class Codes: A61K 31/4985 Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 9/7061 Polyacrylates

Abstract

Provided is a patch containing a drug, a metal salt, an adsorbent and a pressure-sensitive adhesive base, where the metal salt is a salt containing a substance capable of forming a drug salt by bonding to the drug or a component thereof, a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and the adsorbent is an adsorbent that adsorbs a polar solvent contained in the patch.

Claims

1. A patch comprising:

a drug, a metal salt, an adsorbent, and a pressure-sensitive adhesive base, wherein

the metal salt is a salt comprising a substance capable of forming a drug salt by bonding to the drug or a component thereof;

a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed; and

the adsorbent is an adsorbent that adsorbs a polar solvent comprised in the patch.

2. The patch according to claim 1, wherein the metal salt is formed in the patch during production or after production.

3. The patch according to claim 1, wherein the drug is a basic drug.

4. The patch according to claim 1, wherein the metal salt is at least one metal salt selected from the group consisting of metal chlorides, metal bromides, metal iodides and organic acid metal salts.

5. The patch according to claim 1, wherein the metal salt is at least one metal salt selected from the group consisting of sodium chloride, calcium chloride, aluminum chloride, stannous chloride, ferric chloride, magnesium chloride, potassium chloride, sodium citrate, sodium oxalate, sodium tartrate, sodium bromide, and sodium succinate.

6. The patch according to claim 1, wherein the adsorbent is at least one adsorbent selected from the group consisting of talc, kaoline, bentonite, hydrous silica, fumed silica, polyvinylpyrrolidone, propylene glycol, aminoalkyl methacrylate copolymer, crospovidone, carboxy vinyl polymer, lactic acid, acetic acid, zinc oxide, dextrin, and dried aluminum hydroxide gel.

7. The patch according to claim 3, wherein the basic drug is a drug formed from a basic drug acid addition salt.

8. The patch according to claim 7, wherein the basic drug acid addition salt is hydrochloride, acetate, sulfate, maleate, oxalate, citrate, hydroiodide, hydrobromate, mesylate, tartrate or succinate of a basic drug.

9. A patch comprising a backing layer and a pressure-sensitive adhesive layer provided on the backing layer and comprising the patch according to claim 1.

10. A method of suppressing an aggregation and growth of a metal salt present in a pressure-sensitive adhesive layer of a patch, comprising:

providing a patch comprising a drug, the metal salt, an adsorbent and a pressure-sensitive adhesive base,

wherein the metal salt is a salt comprising a substance capable of forming a drug salt by bonding to the drug or a component thereof,

wherein a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and

the adsorbent is an adsorbent that adsorbs a polar solvent comprised in the patch.