Device including altered microorganisms, and methods and systems of use

• US 20110028945A1
• Filed: 05/28/2010
• Published: 02/03/2011
• Est. Priority Date: 12/14/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Zartman, Jeremiah James, Amodei, Dario G., Tegreene, Clarence T., Somogyi, Christopher, Jung, Edward K.Y., Bershteyn, Anna, Eckhoff, Philip A., Bao, Xiaoyan Robert, Kim, Lily Yvonne, Wood, Lowell L. JR., Bethke, Brett, Gustafson, Kyle B., Lieberman, Erez, Esvelt, Kevin Michael, Kaminsky, William Michael, Kare, Jordin T., Moitra, Ankur, Bangera, Mahalaxmi Gita, Leuthardt, Eric C.
• Granted Patent: US 8,682,619 B2
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61K 47/6901 Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/258 Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent.

Claims

1. A system comprising:

at least one computing device;

at least one treatment device including at least one semi-permeable barrier substantially enclosing at least one auxotrophic microorganism, the at least one auxotrophic microorganism including at least one nucleic acid construct encoding at least one therapeutic agent, the barrier defining an interior region and exterior region;

wherein the device includes at least one metabolite required by the at least one auxotrophic microorganism;

the treatment device further comprising at least one pump for dispensing at least one therapeutic agent, the pump including electronic circuitry configured to send or receive signals from the computing device; and

one or more instructions on a recordable medium that when executed on the computing device cause the computing device to regulate dispensing of the at least one therapeutic agent from the at least one treatment device.

2. The system of claim 1, wherein the at least one computing device includes one or more of a desktop computer, phone, personal digital assistant, remote controller, workstation computer, or computing system.

3. The system of claim 2, wherein the at least one computing system includes one or more of a cluster of processors, a networked computer, a tablet personal computer, a laptop computer, a mobile device, a mobile telephone, or a personal digital assistant computer.

4. The system of claim 1, further comprising one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to generate at least one output to a user readable display.

7. The system of claim 4, wherein the user includes at least one entity.

8. The system of claim 7, wherein the entity includes at least one person, or computer.

9. The system of claim 4, wherein the user readable display includes a human readable display.

10. The system of claim 4, wherein the user readable display includes one or more active displays.

11. The system of claim 4, wherein the user readable display includes one or more passive displays.

12. The system of claim 4, wherein the user readable display includes one or more of a numeric format, graphical format, or audio format.

17. The system of claim 1, further comprising one or more instructions on a recordable medium that when executed on the computing device cause the computing device to alter at least one microorganism isolated from at least one biological tissue.

20. The system of claim 1, further comprising one or more instructions on a recordable medium that when executed on the computing device cause the computing device to predetermine at least one microorganism strain or type for altering in order to produce at least one therapeutic agent based on at least one feature of at least one biological tissue.

22. The system of claim 1, further comprising one or more instructions for delivering at least one agent sufficient to induce death in the at least one auxotrophic microorganism.

24. The system of claim 1, further comprising a cryptographic logic component.

25. The system of claim 24, wherein the cryptographic logic component is configured to implement at least one cryptographic process or cryptographic logic.

26. The system of claim 24, wherein the cryptographic logic component is configured to implement one or more processes associated with at least one of a cryptographic protocol, decryption protocol, or encryption protocol.

27. The system of claim 24, wherein the cryptographic logic component is configured to implement one or more processes associated with at least one of a regulatory compliance protocol, regulatory protocol, or authentication protocol.

28. The system of claim 24, wherein the cryptographic logic component is configured to implement one or more processes associated with at least one of an authorization protocol, activation protocol, or treatment regimen protocol.

29. The system of claim 24, wherein the cryptographic logic component includes one or more of a crypto-algorithm, signal-bearing media, crypto controller, or cryptographic module.

30. The system of claim 24, wherein the cryptographic logic component is configured to generate information associated with at least one of an authentication protocol, authorization protocol, anti-microbial agent reservoir delivery protocol, activation protocol, encryption protocol, decryption protocol authorization instruction, prescription dosing instruction, or prescribed regimen instruction.

31. The system of claim 24, wherein the cryptographic logic component is configured to generate information associated with at least one of an activation code, error code, command code, or authorization code.

32. The system of claim 24, wherein the cryptographic logic component is configured to generate information associated with at least one of a cryptographic protocol, decryption protocol, encryption protocol, regulatory compliance protocol, or regulatory use protocol.

5-6. -6. (canceled)

13-16. -16. (canceled)

18-19. -19. (canceled)

21. (canceled)

23. (canceled)

33. A system comprising:

at least one computing device;

one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to receive a first input associated with a first possible dataset,

the first possible dataset including data representative of at least one parameter for making or administering at least one treatment device to at least one biological tissue, wherein the at least one treatment device includes at least one semi-permeable bather structured to substantially enclose at least one auxotrophic microorganism;

wherein the at least one auxotrophic microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent; and

one or more instructions on a recordable medium that when executed on the at least one computing device cause the computing device to generate an output to a user readable display.

34. The system of claim 33, further comprising one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to compare a value associated with the first possible dataset with a second dataset including values of at least one predictive parameter.

35. The system of claim 33, wherein the first input includes one or more values derived from at least one property of the at least one treatment device.

36. The system of claim 33, wherein the first input includes at least one parameter for generating the at least one auxotrophic microorganism.

37. The system of claim 33, wherein the first input includes at least one parameter for making the at least one treatment device.

38. The system of claim 37, wherein the at least one parameter for making the at least one treatment device includes one or more of constitution of the at least one treatment device, configuration of the at least one treatment device, formulation of the at least one therapeutic agent, type of auxotrophic microorganism, strain of auxotrophic microorganism, configuration of the at least one inducible genetic element of the auxotrophic microorganism, or alteration of the at least one auxotrophic microorganism.

39. The system of claim 33, wherein the second input includes one or more values related to the at least one parameter for administering at least one treatment device to the at least one biological tissue.

40. The system of claim 39, wherein the at least one parameter for administering the at least one treatment device includes one or more of:

biological tissue type;

biological tissue function;

biological tissue size;

biological tissue constitution;

biological tissue architecture;

biological tissue durability;

biological tissue temperature;

temperature of administration conditions;

depth of administration of the at least one treatment device;

biological tissue source;

one or more temporal coordinates;

one or more spatial coordinates;

angle of administration of the at least one treatment device;

force of administration of the at least one treatment device;

velocity of administration of the at least one treatment device;

quantity of treatment devices administered;

rate of administration of more than one treatment device;

method of administration of the at least one treatment device;

timing of administration of the at least one treatment device;

rate of production of the at least one therapeutic agent of the at least one treatment device, or rate of dispensing of the at least one therapeutic agent from the at least one treatment device.

41. The system of claim 33, further comprising one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the second possible dataset.

45. The system of claim 33, further comprising one or more instructions on a recordable medium that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the first possible dataset.

46. The system of claim 33, wherein the at least one computing device includes one or more of a desktop computer, workstation computer, phone, personal digital assistant, remote controller, or computing system.

47. The system of claim 33, wherein the at least one computing system includes one or more of a cluster of processors, a networked computer, a tablet personal computer, a laptop computer, a mobile device, a mobile telephone, or a personal digital assistant computer.

48. The system of claim 33, wherein the output includes at least one graphical description of the at least one treatment device, at least one component thereof;

or at least one cell or substance associated with at least one biological tissue.

49. The system of claim 33, wherein the user includes at least one entity.

50. The system of claim 49, wherein the entity includes at least one person, or computer.

51. The system of claim 33, wherein the user readable display includes a human readable display.

52. The system of claim 33, wherein the user readable display includes one or more active displays.

53. The system of claim 33, wherein the user readable display includes one or more passive displays.

54. The system of claim 33, wherein the user readable display includes one or more of a numeric format, graphical format, or audio format.

55. The system of claim 33, further comprising one or more instructions for receiving a third input associated with at least one feature of at least one subject.

59. The system of claim 33, further comprising means for transmitting one or more signals that include information related to the processing of the first input and the second input.

60. The system of claim 59, wherein the means for transmitting one or more signals includes means for transmitting one or more signals associated with selection of at least one parameter for making the at least one treatment device.

61. The system of claim 59, wherein the means for transmitting one or more signals includes means for transmitting one or more signals associated with selection of at least one parameter for administering the at least one treatment device to the at least one biological tissue.

62. The system of claim 59, wherein the means for transmitting one or more signals includes means for transmitting one or more signals associated with comparing the information related to the processing of the first input and the second input.

63. The system of claim 33, further comprising means for generating the at least one auxotrophic microorganism.

64. The system of claim 33, further comprising means for administering the at least one treatment device to at least one biological tissue.

65. The system of claim 33, further comprising means for evaluating the at least one biological tissue for one or more indicators prior to, during, or subsequent to administering the at least one treatment device to at least one biological tissue.

70. The system of claim 33, further comprising means for transmitting one or more signals that include information relating to the accepting a first input or a second input and information related to the evaluating the at least one biological tissue.

71. The system of claim 70, wherein the means for transmitting one or more signals includes means for transmitting one or more signals associated with selection of at least one parameter for making the at least one treatment device.

72. The system of claim 70, wherein the means for transmitting one or more signals includes means for transmitting one or more signals associated with selection of at least one parameter for administering the at least one treatment device.

77. The system of claim 33, further comprising means for predetermining at least one microorganism strain or type for altering to produce at least one therapeutic agent based on at least one feature of at least one biological tissue.

78. The system of claim 77, wherein the at least one feature of the at least one biological tissue includes at least one property of one or more microorganism populations associated with the at least one biological tissue.

42-44. -44. (canceled)

56-58. -58. (canceled)

66-69. -69. (canceled)

73-76. -76. (canceled)