Methods and apparatus for non-invasive determination of patient's blood conditions

• US 20110033385A1
• Filed: 07/14/2010
• Published: 02/10/2011
• Est. Priority Date: 04/03/2006
• Status: Abandoned Application

• Current Assignee: Elfi-Tech Ltd
• Original Assignee: Elfi-Tech Ltd
• Inventors: Shvartsman, Leonid, Fine, Ilya
• Application Number:
  US12/835,998
• Publication Number:
  US 20110033385A1
• Time in Patent Office: Days
• US Class Current: 424/9.1
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time t_ST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow'"'"'s triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period t_m, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated. At least a portion of the measured data and stimulus related data are processed so as to determine a relation between a time function of the at least one stimulus ST(t) and a time function of the measured data OR(t). This relation is indicative of at least one blood circulation and blood coagulation related parameter of the mammal.

Claims

1. A non-invasive method for determination of blood clotting related and blood circulation related parameters of a mammal, the method comprising:

(i) non-invasively inducing at least one stimulus ST in a blood containing medium in the mammal for a preset period of time t_ST, said at least one stimulus being selected to cause at least one of the following to occur;

(a) inducing at least two of three Virchow'"'"'s triad elements including abnormalities of blood flow;

abnormalities of blood constituents and abnormalities of the blood vessel wall, and

(b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity;

(ii) performing non-invasive measurements at a measurement location in the mammal by applying an external field thereto for a preset time period t_M;

detecting a response of the measurement location to the applied field; and

generating measured data indicative thereof; and

(iii) processing at least a portion of the measured data and processing stimulus related data so as to determine a relation between a time function of said at least one stimulus ST(t) and a time function of the measured data OR(t), said relation being indicative of at least one blood circulation and blood coagulation related parameter of the mammal.