SENSOR WITH LONG-TERM STABILITY FOR BIOPROCESSES

• US 20110033917A1
• Filed: 10/09/2008
• Published: 02/10/2011
• Est. Priority Date: 10/11/2007
• Status: Abandoned Application

• Current Assignee: Endress+Hauser GmbH+Co (ENDRESS)
• Original Assignee: Endress + Hauser Conducta Gesellschaft Fur Mess- Und Regeltechnik Mbh + Co. Kg
• Inventors: Trapp, Thilo, Hanko, Michael, Planitzer, Ânnett
• Application Number:
  US12/734,112
• Publication Number:
  US 20110033917A1
• Time in Patent Office: Days
• US Class Current: 435/288.7
• CPC Class Codes: G01N 21/82 producing a precipitate or turbidity
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

A sensor for registering a measured variable of a medium, especially in a bioprocess. The sensor includes a sensor body, wherein at least one surface section of the sensor body can be supplied with the medium, and wherein a condition of this surface section affects the measured value. The sensor is characterized by the fact that the surface section contains a substance with biocidal properties.

Claims

1-10. -10. (canceled)

11. A sensor for registering a measured variable of a medium, especially in a bioprocess, comprising:

a sensor body, wherein;

at least one surface section of said sensor body can be supplied with the medium;

a condition of said at least one surface section affects a measured value; and

in that said at least one surface section contains a substance with biocidal properties.

12. The sensor as claimed in claim 11, wherein:

said at least one surface section contains a substance, which makes difficult, or completely suppresses, protein adsorption on the surface.

13. The sensor as claimed in claim 11, wherein:

said substance with the biocidal properties is a non-toxic substance.

14. The sensor as claimed in one of claims 11, wherein:

said substance is hydrophilic and/or water soluble.

15. The sensor as claimed in claim 11, wherein:

said substance is anchored on the surface in such a manner in the region of said at least one surface section, that it is not released into the medium under bioprocess conditions.

16. The sensor as claimed in claim 11, wherein:

said substance in said at least one surface section survives at least one cleaning, or sterilizing, essentially undamaged, or without dissolving from said at least one surface section.

17. The sensor as claimed in claim 11, wherein:

said substance comprises polyethylene glycol, which is immobilized on the surface of the body in the region of said at least one surface section.

18. The sensor as claimed in claim 11, wherein:

said substance is anchored on a surface section of glass and/or ceramic by means of at least one silane species, especially 3-aminopropyltriethoxysilane (APTES).

19. The sensor as claimed in claim 11, wherein:

the sensor is a potentiometric sensor, especially a pH sensor, in the form of a single-rod measuring chain or in the form of two separated half cells; and

said at least one surface section, which contains the substance with the biocidal properties, can comprise a pH, glass membrane and/or a diaphragm of a reference half-cell.

20. The sensor as claimed in claim 11, wherein:

the sensor is an optical sensor; and

said at least one surface section, which contains the substance with the biocidal properties, comprises windows or other optical elements, through which radiation of the sensor interacts with a measured medium, or through whose media contacting surface radiation of the sensor is coupled in or out.