NANOPARTICLE-MEDIATED MICROWAVE TREATMENT METHODS
First Claim
1. A method for treating a cell or tissue of interest in a subject in need thereof comprising the steps ofintroducing microwave-active nanoparticles into the cell or tissue;
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the microwave-active nanoparticles react to microwave energy of the microwave field by releasing heat, andthe tissue is heated, thereby inducing hyperthermia or thermotherapy in the tissue.
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Accused Products
Abstract
A method is provided for using magnetic nanoparticles to enhance microwave therapies for treating cells and tissues. The nanoparticles are designed to transduce microwave radiation into heat and furthermore, the nanoparticles may include specific tissue targeting and other functionality for enhancing in situ effects. In one embodiment, nanoparticles are introduced into a tissue system and a microwave field is applied. The nanoparticles react to the microwave energy by releasing heat thus heating the tissue and inducing hyperthermia (below 50° C.) or thermotherapy (above 50° C.). The nanoparticles can be designed for optimal heat production response at specific microwave frequencies and/or ranges of microwave frequencies where these frequencies may span the entire microwave spectrum, namely 300 MHz (3108 Hz) to 300 GHz (31011 Hz).
15 Citations
22 Claims
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1. A method for treating a cell or tissue of interest in a subject in need thereof comprising the steps of
introducing microwave-active nanoparticles into the cell or tissue; - and
applying a microwave field, wherein; the microwave-active nanoparticles react to microwave energy of the microwave field by releasing heat, and the tissue is heated, thereby inducing hyperthermia or thermotherapy in the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for treating cancerous tissue in a subject in need thereof comprising the steps of introducing microwave-active nanoparticles into the cancerous tissue;
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applying a microwave field, wherein; the microwave-active nanoparticles react to microwave, energy of the microwave field by releasing heat, and the cancerous tissue is heated, thereby inducing hyperthermia in the cancerous tissue. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A nanoparticle for treating a cell or tissue of interest, wherein the nanoparticle is:
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tuned to interact with microwaves such that the nanoparticle is more lossy in the presence of microwaves than the cells or tissue of interest are, and functionalized with a functional coating. - View Dependent Claims (18, 19, 20, 21)
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22. A system for controlling effects of a field of microwave radiation in a cell or tissue of interest in a subject in need thereof comprising:
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a source of microwave radiation; an electronic system for monitoring of the microwave radiation; a system for delivery of the microwave radiation to the cell or tissue; microwave-active nanoparticles that absorb the microwave radiation; an injection or administration system for administration of the nanoparticles; wherein; the microwave-active nanoparticles react to microwave energy of the field of microwave radiation by releasing heat, and the cell or tissue is heated, thereby inducing hyperthermia or thermotherapy in the cell or tissue, and whereby the effects of the field of microwave radiation are controlled.
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Specification