ENDOPROSTHESIS AND METHOD FOR PRODUCING SAME

• US 20110034991A1
• Filed: 10/12/2010
• Published: 02/10/2011
• Est. Priority Date: 08/07/2006
• Status: Abandoned Application

• Current Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Inventors: Gerold, Bodo, Fringes, Matthias, Barthel, Harald, Riedmueller, Johannes
• Application Number:
  US12/902,567
• Publication Number:
  US 20110034991A1
• Time in Patent Office: Days
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: B23K 2103/42 Plastics B23K2103/16 takes precedence
• CPC Class Codes: B23K 2103/50 Inorganic material, e.g. metals, not provided for in B23K2103/02 – B23K2103/26

Abstract

An endoprosthesis, in particular, an intraluminal endoprosthesis, e.g., a stent, having a basic mesh and a functional element attached to a carrier structure, the functional element having a different material composition than the material of the basic mesh in at least a portion of its volume. The carrier structure is arranged on the basic mesh in the first essentially finger-shaped end and protrudes away from the mesh essentially like a projection. The functional element is arranged on an area of the carrier structure protruding away from the base body and at least partially surrounds the area of the carrier structure.

Claims

1. An endoprosthesis, in particular an intraluminal endoprosthesis, such as a stent, comprising:

(a) a basic mesh; and

(b) a functional element having a first end attached to a carrier structure and having a second end and having a different material composition in at least a portion of the volume of the functional element in comparison with the material of the basic mesh,

wherein the carrier structure is arranged on the basic mesh on the first essentially finger-shaped end and protrudes away from the basic mesh, and

wherein the carrier structure has a plurality of branches in the area of the second end, and

wherein the functional element is arranged on an area of the carrier structure that protrudes away from the base body and at least partially surrounds the area of the carrier structure.

2. The endoprosthesis of claim 1, wherein the functional element completely surrounds the second end of the carrier structure that protrudes away from the basic mesh.

3. The endoprosthesis of claim 1, wherein the functional element has a droplet shape, a disk shape or a spherical shape.

4. The endoprosthesis of claim 1, wherein the functional element consists at least partially of a radiopaque material.

5. The endoprosthesis of claim 4, wherein the radiopaque material comprises one or more of the elements selected from the group consisting of gold, platinum, silver, tungsten, iodine, tantalum, yttrium, niobium, molybdenum, ruthenium, rhodium, barium, lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, hafnium, rhenium, osmium and bismuth and one or more of the radiopaque compounds from these elements and barium sulfate, bismuth trioxide, bromine, iodine, iodide, titanium oxide and zirconium oxide.

6. The endoprosthesis of claim 1, wherein the functional element contains at least one pharmaceutically active substance.

7. The endoprosthesis of claim 6, wherein the at least one pharmaceutically active substance comprises one or more substances selected from the group of active ingredients consisting of calcium channel blockers, lipid regulators (e.g., fibrates), immunosuppressants, calcineurine inhibitors (e.g., tacrolimus), antiphlogistics (e.g., cortisone or diclofenac), anti-inflammatories (e.g., imidazoles), antiallergics, oligonucleotides (e.g., dODN), estrogens (e.g., genistein), endothelium-forming agents (e.g., fibrin), steroids, proteins/peptides and vasodilators (e.g., sartanes).

8. The endoprosthesis of claim 1, wherein the carrier structure is made of the same material as the basic mesh.

9. The endoprosthesis of claim 1, wherein the carrier structure is made at least partially of an electrically insulating material.

10. The endoprosthesis of claim 1, wherein the carrier structure is provided with an electrically insulating coating at least in the area in which the functional element is arranged on the carrier structure.

11. The endoprosthesis of claim 1, further comprising a plurality of carrier structures having functional elements containing a pharmaceutically active substance and which are arranged in uniform distribution over the entire wall of the mesh structure.

12. The endoprosthesis of claim 1, wherein the endoprosthesis has a plurality of carrier structures with functional elements with radiopaque material, which are arranged on the distal or proximal end of the endoprosthesis, preferably being arranged on a circumferential line.

13. The endoprosthesis of claim 6, wherein the pharmaceutically active substance has an anti-inflammatory, spasmolytic or antiproliferative effect.

14. The endoprosthesis of claim 14, wherein the electrically insulating material is plastic or ceramic.

15. An endoprosthesis, in particular an intraluminal endoprosthesis, such as a stent, comprising:

(a) a basic mesh; and

(b) a functional element having a first end attached to a carrier structure and having a second end and having a different material composition in at least a portion of its volume in comparison with the material of the basic mesh,

wherein the carrier structure is arranged on the basic mesh on the first essentially finger-shaped end and protrudes away from the basic mesh,

wherein the carrier structure has a plurality of fractal branches proximate to the second end, and

wherein the functional element is arranged on an area of the carrier structure that protrudes away from the base body and at least partially surrounds the area of the carrier structure.

16. An endoprosthesis, in particular an intraluminal endoprosthesis, such as a stent, comprising:

(a) a generally cylindrical shaped mesh structure made of a first material and having at least one finger-shaped first end and a second end, the second end having a plurality of fractal branches proximate thereto;

(b) a carrier structure arranged on the basic mesh on the first essentially finger-shaped end and protruding away from the mesh structure; and

,

(c) a functional element attached to the carrier structure and proximate to an area of the carrier structure that protrudes away from the mesh structure and at least partially surrounds the area of the carrier structure, at least a portion of the volume of the functional element being made of a material different than the first material.