Anti-adhesion device

• US 20110035026A1
• Filed: 07/19/2010
• Published: 02/10/2011
• Est. Priority Date: 05/20/2004
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: David M. Hoganson
• Inventors: Hoganson, David M.
• Granted Patent: US 8,361,164 B2
• Time in Patent Office: Days
• US Class Current: 623/23.74
• CPC Class Codes: A61B 17/085 with adhesive layer
• CPC Class Codes: A61B 2017/081 Tissue approximator A61B2017/1103, A61B17/8866 take precedence
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2002/0068 having a special mesh pattern
• CPC Class Codes: A61F 2002/0072 Delivery tools therefor
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions.

Claims

1. A method for preventing the formation of adhesions following a surgical procedure comprising the step of placing a device between two tissues, said device comprising a plurality of layers, wherein said plurality of layers comprises at least an anterior layer and a posterior layer, said anterior and posterior layers each having an outer and inner surface, said outer surfaces serving to resist adhesion to tissue, said plurality of layers having at least one releasable attachment means arranged between said layers and attaching said layers together, wherein after implantation, said releasable attachment releases, whereupon said plurality of layers are completely releasably separate.

2. The method of claim 1, wherein at least a portion of at least one of said layers comprises a plurality of pores.

3. The method of claim 1, wherein the inner surfaces of said anterior and posterior layers are substantially non-porous.

4. The method of claim 3, wherein the outer surfaces of said anterior and posterior layers are porous.

5. The method of claim 1, further comprising at least one additive component.

6. The method of claim 5, wherein said additive component comprises at least one of biologically active agent, carrier material, fibrous material, particulate material, plasticizer, and combinations thereof.

7. The method of claim 5, wherein said additive component comprises a biologically active agent, said biologically active agent being arranged to be delivered by the device through a period of finite duration.

8. The method of claim 10 wherein said biologically active agent is released at a controlled rate.

9. The method of claim 1, further comprising at least one intervening layer of material between said anterior and posterior layers, said intervening layer being arranged to reduce adhesion or friction between said anterior and posterior layers.

10. The method of claim 1, wherein said releasable attachment means comprises at least one of sutures, staples, clips, magnets, static bonds, physically interlocking components, adhesives, salts, carbohydrates, gelatins, hydrogels and combinations thereof.

11. The method of claim 1, wherein said releasable attachment means is resorbable.

12. The method of claim 11, wherein said plurality of layers are resorbable.

13. The method of claim 12, wherein said releasable attachment means is resorbed faster than said layers.

14. The method of claim 1, wherein said layers are attached by said releasable attachment means through at least one point.

15. The method of claim 1, wherein said layers are attached by said releasable attachment means along at least one edge.

16. The method of claim 3, wherein said substantially non-porous layers are impermeable to fluid.

17. The method of claim 1, further comprising a locating means.

18. The method of claim 1, further comprising securing means being arranged to secure said device to tissue, said securing means comprising at least one of adhesive, suture, tabs, magnets and staples and at least one loop arranged on said outer surfaces of said device.

19. The method of claim 1, further comprising the step of securing said device to said tissue.

20. The method of claim 17, wherein said locating means comprises at least one locating limb.

21. The method of claim 20, wherein said locating limb may be attached to at least one of said outer surface and said inner surface.

22. The method of claim 20, wherein a single locating limb is attached to at least one of said outer surface and said inner surface at multiple locations.

23. The method of claim 1, wherein at least one layer comprises a non-resorbable material.

24. The method of claim 5, wherein said additive component comprises at least one of an adhesion promoter material and an adhesion retarding material.

25. The method of claim 5, wherein said additive component comprises at least one structural agent.

26. The method of claim 1, arranged to promote local adhesions of at least two tissues to one another.

27. The method of claim 1, further comprising at least one reinforcing material.