PROSTHETIC MATERIAL FOR LIVING ORGAN

• US 20110038911A1
• Filed: 07/25/2008
• Published: 02/17/2011
• Est. Priority Date: 08/09/2007
• Status: Abandoned Application

• Current Assignee: Gunze Limited
• Original Assignee: Gunze Limited
• Inventors: Ikada, Yoshito, Matsuda, Shojiro, Ichihara, Yuki, Shinoka, Toshiharu, Sakamoto, Yuki
• Application Number:
  US12/672,017
• Publication Number:
  US 20110038911A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3834 Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: Y10T 428/249953 Composite having voids in a component [e.g., porous, cellular, etc.]
• CPC Class Codes: Y10T 442/60 Nonwoven fabric [i.e., nonwoven strand or fiber material]

Abstract

It is an object of the invention to provide a prosthetic material for living organs, which can sufficiently withstand the arterial pressure and thereby can prevent leakage of blood or rupture of blood vessels, and which serves as a scaffold for vascular tissue regeneration, and does not necessitate repeated surgeries or the like.

The invention is a prosthetic material for living organs, which comprises a laminate including a film layer and a porous layer, said film layer comprising a bioabsorbable material, said porous layer comprising a bioabsorbable material.

Claims

1. A prosthetic material for living organs,

which comprises a laminate including a film layer and a porous layer,

said film layer comprising a bioabsorbable material,

said porous layer comprising a bioabsorbable material.

2. The prosthetic material for living organs according to claim 1,

wherein the bioabsorbable material constituting the film layer is a synthetic absorbable polymer or a naturally occurring polymer.

3. The prosthetic material for living organs according to claim 1,

wherein the thickness of the film layer is in the range of 30 μ

m to 1 mm.

4. The prosthetic material for living organs according to claim 2,

wherein the synthetic absorbable polymer is at least one selected from lactide (D-, L- or DL-isomer)-ε

-caprolactone copolymers, glycolide-ε

-caprolactone copolymers, and glycolide-lactide (D-, L-, or DL-isomer)-ε

-caprolactone copolymers.

5. The prosthetic material for living organs according to claim 2,

wherein the naturally occurring polymer is at least one selected from gelatin, collagen and fibrin.

6. The prosthetic material for living organs according to claim 1,

wherein the porous layer is formed from a non-woven fabric, a sponge, or a composite of a non-woven fabric and a sponge.

7. The prosthetic material for living organs according to claim 1,

wherein the bioabsorbable material constituting the porous layer is at least one selected from lactide (D-, L- or DL-isomer)-ε

-caprolactone copolymers, glycolide-ε

-caprolactone copolymers, and glycolide-lactide (D-, L-, or DL-isomer)-ε

-caprolactone copolymers.

8. The prosthetic material for living organs according to claim 6,

wherein the mass per unit area of the non-woven fabric layer is in the range of 35 to 300 g/m².

9. The prosthetic material for living organs according to claim 1,

wherein the bending stiffness of the prosthetic material, which is measured by a method equivalent to the cantilever test method stipulated in the bending stiffness A method of JIS L-1096 using a specimen having a size of 2 cm×

10 cm, is 10 cm or less.

10. The prosthetic material for living organs according to claim 1,

wherein a drug is soaked into the porous layer.

11. The prosthetic material for living organs according to claim 1,

wherein cells are seeded in vitro in the porous layer.

12. The prosthetic material for living organs according to claim 11,

wherein the seeded cells are bone marrow cells.