DNA SEQUENCE WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS
First Claim
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1. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
- a) contacting a plurality of the nucleic acids with (i) a dideoxynucleotide triphosphate (ddNTP) analogue having the structure;
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Abstract
This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.
95 Citations
42 Claims
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1. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
a) contacting a plurality of the nucleic acids with (i) a dideoxynucleotide triphosphate (ddNTP) analogue having the structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11-27. -27. (canceled)
- 28. A compound having the structure:
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34. (canceled)
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35. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
a) contacting a plurality of the nucleic acids with (i) at least four different dideoxynucleotide triphosphate (ddNTP) analogues, each having the structure; - View Dependent Claims (36, 37, 38, 39, 40, 41)
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42-59. -59. (canceled)
Specification